Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors

Chordoma is a rare malignant bone tumor arising from notochordal tissue. Conventional treatments, such as radical resection and high-dose irradiation, frequently fail to control the tumor, resulting in recurrence and re-growth. In this study, genetic analysis of the tumor in a 72-year-old male patie...

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Detalles Bibliográficos
Autores principales: Shinojima, Naoki, Ozono, Kazutaka, Yamamoto, Haruaki, Abe, Sakiko, Sasaki, Rumi, Tomita, Yusuke, Kai, Azusa, Mori, Ryosuke, Yamamoto, Takahiro, Uekawa, Ken, Matsui, Hirotaka, Nosaka, Kisato, Matsuzaki, Hiroaki, Komohara, Yoshihiro, Mikami, Yoshiki, Mukasa, Akitake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314830/
https://www.ncbi.nlm.nih.gov/pubmed/37086325
http://dx.doi.org/10.1007/s10014-023-00461-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314830/
https://www.ncbi.nlm.nih.gov/pubmed/37086325
http://dx.doi.org/10.1007/s10014-023-00461-w

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