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Targeting NAD metabolism regulates extracellular adenosine levels to improve the cytotoxicity of CD8+ effector T cells in the tumor microenvironment of gastric cancer

PURPOSE: Nicotinamide adenine dinucleotide (NAD+) is closely related to the pathogenesis of tumors. However, the effect of NAD+ metabolism of gastric cancer (GC) cells on immune cells remains unexplained. We targeted nicotinamide phosphoribosyltransferase (NAMPT), a rate-limiting enzyme in the NAD+...

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Detalles Bibliográficos
Autores principales:	Liu, Han-Yuan, Wang, Fu-Hui, Liang, Jian-Ming, Xiang, Yuan-Yuan, Liu, Shu-Hao, Zhang, Shi-Wei, Zhu, Cheng-Ming, He, Yu-Long, Zhang, Chang-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314862/ https://www.ncbi.nlm.nih.gov/pubmed/35776198 http://dx.doi.org/10.1007/s00432-022-04124-9

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