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Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study
PURPOSE: Basal cell carcinoma (BCC) is the most diagnosed type of cancer accounting for 80% of all keratinocyte malignancies. However, the exact demographic properties and clinicopathological criteria for BCC in Egyptians are not clearly reported. Our aim is to report and analyze the epidemiological...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314874/ https://www.ncbi.nlm.nih.gov/pubmed/35870014 http://dx.doi.org/10.1007/s00432-022-04207-7 |
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author | El-Khalawany, Mohamed Hassab-El-Naby, Hussein M. M. Mousa, Ahmed Mustafa Sameh, Ahmed Rageh, Mahmoud A. Genedy, Rasha Mahmoud Hosny, Aya Magdy Aboelmagd, Marwa A. Aboeldahab, Soha |
author_facet | El-Khalawany, Mohamed Hassab-El-Naby, Hussein M. M. Mousa, Ahmed Mustafa Sameh, Ahmed Rageh, Mahmoud A. Genedy, Rasha Mahmoud Hosny, Aya Magdy Aboelmagd, Marwa A. Aboeldahab, Soha |
author_sort | El-Khalawany, Mohamed |
collection | PubMed |
description | PURPOSE: Basal cell carcinoma (BCC) is the most diagnosed type of cancer accounting for 80% of all keratinocyte malignancies. However, the exact demographic properties and clinicopathological criteria for BCC in Egyptians are not clearly reported. Our aim is to report and analyze the epidemiological and clinicopathological features of BCC in Egyptians. METHODS: We retrospectively reviewed the medical records for patients diagnosed pathologically with BCC during the period from January 2017 to December 2021. Data were recruited from four dermatology centers with different geographical distributions. RESULTS: We registered 544 patients. Their age ranged between 22–91 years with a mean of 61.6 ± 13.2 years. Females showed younger age of onset. The mean duration of the tumor was 3.9 ± 3.8 years. The most common involved region was the head (79.4%), and about one third of patients (32.2%) had a giant lesion (> 5 cm). The most common clinical presentation was ulcerative lesions (44.9%). Pathologically, the nodular type represented the most common variant (50.4%). CONCLUSION: Our results proposed that the annual incidence of BCC is increasing among Egyptians. Ultraviolet radiation is considered a high-risk factor of BCC leading to a higher affection of the head region and more prevalence in men. This study also highlights some criteria of BCC in Egyptians such as the long duration of the tumor, the early onset in females, the higher percentage of giant types, and the predominance of nodular type. To our knowledge, this is the first report describing the characteristic features of BCC among Egyptians. |
format | Online Article Text |
id | pubmed-10314874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-103148742023-07-03 Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study El-Khalawany, Mohamed Hassab-El-Naby, Hussein M. M. Mousa, Ahmed Mustafa Sameh, Ahmed Rageh, Mahmoud A. Genedy, Rasha Mahmoud Hosny, Aya Magdy Aboelmagd, Marwa A. Aboeldahab, Soha J Cancer Res Clin Oncol Research PURPOSE: Basal cell carcinoma (BCC) is the most diagnosed type of cancer accounting for 80% of all keratinocyte malignancies. However, the exact demographic properties and clinicopathological criteria for BCC in Egyptians are not clearly reported. Our aim is to report and analyze the epidemiological and clinicopathological features of BCC in Egyptians. METHODS: We retrospectively reviewed the medical records for patients diagnosed pathologically with BCC during the period from January 2017 to December 2021. Data were recruited from four dermatology centers with different geographical distributions. RESULTS: We registered 544 patients. Their age ranged between 22–91 years with a mean of 61.6 ± 13.2 years. Females showed younger age of onset. The mean duration of the tumor was 3.9 ± 3.8 years. The most common involved region was the head (79.4%), and about one third of patients (32.2%) had a giant lesion (> 5 cm). The most common clinical presentation was ulcerative lesions (44.9%). Pathologically, the nodular type represented the most common variant (50.4%). CONCLUSION: Our results proposed that the annual incidence of BCC is increasing among Egyptians. Ultraviolet radiation is considered a high-risk factor of BCC leading to a higher affection of the head region and more prevalence in men. This study also highlights some criteria of BCC in Egyptians such as the long duration of the tumor, the early onset in females, the higher percentage of giant types, and the predominance of nodular type. To our knowledge, this is the first report describing the characteristic features of BCC among Egyptians. Springer Berlin Heidelberg 2022-07-23 2023 /pmc/articles/PMC10314874/ /pubmed/35870014 http://dx.doi.org/10.1007/s00432-022-04207-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research El-Khalawany, Mohamed Hassab-El-Naby, Hussein M. M. Mousa, Ahmed Mustafa Sameh, Ahmed Rageh, Mahmoud A. Genedy, Rasha Mahmoud Hosny, Aya Magdy Aboelmagd, Marwa A. Aboeldahab, Soha Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study |
title | Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study |
title_full | Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study |
title_fullStr | Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study |
title_full_unstemmed | Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study |
title_short | Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study |
title_sort | epidemiological and clinicopathological analysis of basal cell carcinoma in egyptian population: a 5-year retrospective multicenter study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314874/ https://www.ncbi.nlm.nih.gov/pubmed/35870014 http://dx.doi.org/10.1007/s00432-022-04207-7 |
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