Ritanserin suppresses acute myeloid leukemia by inhibiting DGKα to downregulate phospholipase D and the Jak-Stat/MAPK pathway

Refractory or relapsed (R/R) AML is the most challenging form of AML to treat. Due to frequent genetic mutations, therapy alternatives are limited. Here, we identified the role of ritanserin and its target DGKα in AML. Several AML cell lines and primary patient cells were treated with ritanserin and...

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Detalles Bibliográficos
Autores principales: Tan, Jinshui, Zhong, Mengya, Hu, Yanyan, Pan, Guangchao, Yao, Jingwei, Tang, Yuanfang, Duan, Hongpeng, Jiang, Yuelong, Shan, Weihang, Lin, Jiaqi, Liu, Yating, Huang, Jiewen, Zheng, Huijian, Zhou, Yong, Fu, Guo, Li, Zhifeng, Xu, Bing, Zha, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314883/
https://www.ncbi.nlm.nih.gov/pubmed/37392305
http://dx.doi.org/10.1007/s12672-023-00737-9

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