Rapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune response

Charcot-Marie-Tooth disease is a chronic hereditary motor and sensory polyneuropathy targeting Schwann cells and/or motor neurons. Its multifactorial and polygenic origin portrays a complex clinical phenotype of the disease with a wide range of genetic inheritance patterns. The disease-associated ge...

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Detalles Bibliográficos
Autores principales: León, Marian, Prieto, Javier, Molina-Navarro, María Micaela, García-García, Francisco, Barneo-Muñoz, Manuela, Ponsoda, Xavier, Sáez, Rosana, Palau, Francesc, Dopazo, Joaquín, Izpisua Belmonte, Juan Carlos, Torres, Josema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314916/
https://www.ncbi.nlm.nih.gov/pubmed/37393339
http://dx.doi.org/10.1038/s41420-023-01531-w

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