Mutational signatures reveal mutual exclusivity of homologous recombination and mismatch repair deficiencies in colorectal and stomach tumors

Decomposing somatic mutation spectra into mutational signatures and their corresponding etiologies provides a powerful approach for investigating the mechanism of DNA damage and repair. Assessing microsatellite (in)stability (MSI/MSS) status and interpreting their clinical relevance in different mal...

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Detalles Bibliográficos
Autores principales: Farmanbar, Amir, Kneller, Robert, Firouzi, Sanaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314920/
https://www.ncbi.nlm.nih.gov/pubmed/37393385
http://dx.doi.org/10.1038/s41597-023-02331-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314920/
https://www.ncbi.nlm.nih.gov/pubmed/37393385
http://dx.doi.org/10.1038/s41597-023-02331-8

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