The role of CXCL family members in different diseases

Chemokines are a large family mediating a lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily possesses the same ability. CXC chemokines can recruit and migrate different categories of immune cells, regulate tumor’s path...

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Autores principales: Zhou, Chenjia, Gao, Ying, Ding, Peilun, Wu, Tao, Ji, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314943/
https://www.ncbi.nlm.nih.gov/pubmed/37393391
http://dx.doi.org/10.1038/s41420-023-01524-9
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author Zhou, Chenjia
Gao, Ying
Ding, Peilun
Wu, Tao
Ji, Guang
author_facet Zhou, Chenjia
Gao, Ying
Ding, Peilun
Wu, Tao
Ji, Guang
author_sort Zhou, Chenjia
collection PubMed
description Chemokines are a large family mediating a lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily possesses the same ability. CXC chemokines can recruit and migrate different categories of immune cells, regulate tumor’s pathological behaviors like proliferation, invasion and metastasis, activate angiogenesis, etc. Due to these characteristics, CXCL subfamily is extensively and closely associated with tumors and inflammatory diseases. As studies are becoming more and more intensive, CXCLs’ concrete roles are better described, and CXCLs’ therapeutic applications including biomarkers and targets are also deeply explained. In this review, the role of CXCL family members in various diseases is summarized.
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spelling pubmed-103149432023-07-03 The role of CXCL family members in different diseases Zhou, Chenjia Gao, Ying Ding, Peilun Wu, Tao Ji, Guang Cell Death Discov Review Article Chemokines are a large family mediating a lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily possesses the same ability. CXC chemokines can recruit and migrate different categories of immune cells, regulate tumor’s pathological behaviors like proliferation, invasion and metastasis, activate angiogenesis, etc. Due to these characteristics, CXCL subfamily is extensively and closely associated with tumors and inflammatory diseases. As studies are becoming more and more intensive, CXCLs’ concrete roles are better described, and CXCLs’ therapeutic applications including biomarkers and targets are also deeply explained. In this review, the role of CXCL family members in various diseases is summarized. Nature Publishing Group UK 2023-07-01 /pmc/articles/PMC10314943/ /pubmed/37393391 http://dx.doi.org/10.1038/s41420-023-01524-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Zhou, Chenjia
Gao, Ying
Ding, Peilun
Wu, Tao
Ji, Guang
The role of CXCL family members in different diseases
title The role of CXCL family members in different diseases
title_full The role of CXCL family members in different diseases
title_fullStr The role of CXCL family members in different diseases
title_full_unstemmed The role of CXCL family members in different diseases
title_short The role of CXCL family members in different diseases
title_sort role of cxcl family members in different diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314943/
https://www.ncbi.nlm.nih.gov/pubmed/37393391
http://dx.doi.org/10.1038/s41420-023-01524-9
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