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Syncope and the Inability to Move: Was It the Magnesium?

Proton pump inhibitors (PPIs) were clinically introduced more than 30 years ago and have been a very safe and effective agent for the treatment of a variety of different acid-base disorders. PPIs work by inhibiting the final step in gastric acid synthesis production by covalently binding to the (H+,...

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Autores principales: Perkins, David R, Kandah, Omar, Check, Larissa, Sherertz, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315067/
https://www.ncbi.nlm.nih.gov/pubmed/37404409
http://dx.doi.org/10.7759/cureus.39868
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author Perkins, David R
Kandah, Omar
Check, Larissa
Sherertz, Robert
author_facet Perkins, David R
Kandah, Omar
Check, Larissa
Sherertz, Robert
author_sort Perkins, David R
collection PubMed
description Proton pump inhibitors (PPIs) were clinically introduced more than 30 years ago and have been a very safe and effective agent for the treatment of a variety of different acid-base disorders. PPIs work by inhibiting the final step in gastric acid synthesis production by covalently binding to the (H+,K+)-ATPase enzyme system at the level of the gastric parietal cells leading to the irreversible inhibition of gastric acid secretion until new enzymes are produced. This inhibition is useful in a wide variety of disorders, which include, but are not limited to, gastroesophageal reflux disease (GERD), peptic ulcer disease, erosive esophagitis, Helicobacter pylori infection, and pathological hypersecretory disorders. Despite PPIs’ overall excellent safety profile, PPIs have raised concerns about both short- and long-term complications including multiple electrolyte derangements that can lead to life-threatening situations. We present a case of a 68-year-old male who presented to the emergency department after a syncopal episode with profound weakness and was found to have undetectable magnesium levels secondary to long-term omeprazole use. This case report highlights how important it is for clinicians to be aware of these electrolyte disturbances and the importance of monitoring electrolytes while being on these medications.
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spelling pubmed-103150672023-07-03 Syncope and the Inability to Move: Was It the Magnesium? Perkins, David R Kandah, Omar Check, Larissa Sherertz, Robert Cureus Internal Medicine Proton pump inhibitors (PPIs) were clinically introduced more than 30 years ago and have been a very safe and effective agent for the treatment of a variety of different acid-base disorders. PPIs work by inhibiting the final step in gastric acid synthesis production by covalently binding to the (H+,K+)-ATPase enzyme system at the level of the gastric parietal cells leading to the irreversible inhibition of gastric acid secretion until new enzymes are produced. This inhibition is useful in a wide variety of disorders, which include, but are not limited to, gastroesophageal reflux disease (GERD), peptic ulcer disease, erosive esophagitis, Helicobacter pylori infection, and pathological hypersecretory disorders. Despite PPIs’ overall excellent safety profile, PPIs have raised concerns about both short- and long-term complications including multiple electrolyte derangements that can lead to life-threatening situations. We present a case of a 68-year-old male who presented to the emergency department after a syncopal episode with profound weakness and was found to have undetectable magnesium levels secondary to long-term omeprazole use. This case report highlights how important it is for clinicians to be aware of these electrolyte disturbances and the importance of monitoring electrolytes while being on these medications. Cureus 2023-06-02 /pmc/articles/PMC10315067/ /pubmed/37404409 http://dx.doi.org/10.7759/cureus.39868 Text en Copyright © 2023, Perkins et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Perkins, David R
Kandah, Omar
Check, Larissa
Sherertz, Robert
Syncope and the Inability to Move: Was It the Magnesium?
title Syncope and the Inability to Move: Was It the Magnesium?
title_full Syncope and the Inability to Move: Was It the Magnesium?
title_fullStr Syncope and the Inability to Move: Was It the Magnesium?
title_full_unstemmed Syncope and the Inability to Move: Was It the Magnesium?
title_short Syncope and the Inability to Move: Was It the Magnesium?
title_sort syncope and the inability to move: was it the magnesium?
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315067/
https://www.ncbi.nlm.nih.gov/pubmed/37404409
http://dx.doi.org/10.7759/cureus.39868
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