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Antigen Delivery Systems: Past, Present, and Future
The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would also contribute to global well-being. For successful vaccine devel...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Applied Pharmacology
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315343/ https://www.ncbi.nlm.nih.gov/pubmed/37072288 http://dx.doi.org/10.4062/biomolther.2023.006 |
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author | Ko, Hyun-Jeong Kim, Yeon-Jeong |
author_facet | Ko, Hyun-Jeong Kim, Yeon-Jeong |
author_sort | Ko, Hyun-Jeong |
collection | PubMed |
description | The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would also contribute to global well-being. For successful vaccine development, the advancement of technologies such as antigen (Ag) screening, Ag delivery systems and adjuvants, and manufacturing processes is essential. Ag delivery systems are required not only to deliver a sufficient amount of Ag for vaccination, but also to enhance immune response. In addition, Ag types and their delivery systems determine the manufacturing processes of the vaccine product. Here, we analyze the characteristics of various Ag delivery systems: plasmids, viral vectors, bacterial vectors, nanoparticles, self-assembled particles, natural and artificial cells, and extracellular vesicles. This review provides insight into the current vaccine landscape and highlights promising avenues of research for the development and improvement of Ag delivery systems. |
format | Online Article Text |
id | pubmed-10315343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Society of Applied Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-103153432023-07-04 Antigen Delivery Systems: Past, Present, and Future Ko, Hyun-Jeong Kim, Yeon-Jeong Biomol Ther (Seoul) Review The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would also contribute to global well-being. For successful vaccine development, the advancement of technologies such as antigen (Ag) screening, Ag delivery systems and adjuvants, and manufacturing processes is essential. Ag delivery systems are required not only to deliver a sufficient amount of Ag for vaccination, but also to enhance immune response. In addition, Ag types and their delivery systems determine the manufacturing processes of the vaccine product. Here, we analyze the characteristics of various Ag delivery systems: plasmids, viral vectors, bacterial vectors, nanoparticles, self-assembled particles, natural and artificial cells, and extracellular vesicles. This review provides insight into the current vaccine landscape and highlights promising avenues of research for the development and improvement of Ag delivery systems. The Korean Society of Applied Pharmacology 2023-07-01 2023-04-19 /pmc/articles/PMC10315343/ /pubmed/37072288 http://dx.doi.org/10.4062/biomolther.2023.006 Text en Copyright © 2023, The Korean Society of Applied Pharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Ko, Hyun-Jeong Kim, Yeon-Jeong Antigen Delivery Systems: Past, Present, and Future |
title | Antigen Delivery Systems: Past, Present, and Future |
title_full | Antigen Delivery Systems: Past, Present, and Future |
title_fullStr | Antigen Delivery Systems: Past, Present, and Future |
title_full_unstemmed | Antigen Delivery Systems: Past, Present, and Future |
title_short | Antigen Delivery Systems: Past, Present, and Future |
title_sort | antigen delivery systems: past, present, and future |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315343/ https://www.ncbi.nlm.nih.gov/pubmed/37072288 http://dx.doi.org/10.4062/biomolther.2023.006 |
work_keys_str_mv | AT kohyunjeong antigendeliverysystemspastpresentandfuture AT kimyeonjeong antigendeliverysystemspastpresentandfuture |