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Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts

3D printing has provided a new prospective in the manufacturing of personalized medical implants, including fistulas for haemodialysis (HD). In the current study, an optimized fused modelling deposition (FDM) 3D printing method has been validated, for the first time, to obtain cylindrical shaped fis...

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Autores principales: Basile, Sara, Mathew, Essyrose, Genta, Ida, Conti, Bice, Dorati, Rossella, Lamprou, Dimitrios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315350/
https://www.ncbi.nlm.nih.gov/pubmed/34642844
http://dx.doi.org/10.1007/s13346-021-01078-2
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author Basile, Sara
Mathew, Essyrose
Genta, Ida
Conti, Bice
Dorati, Rossella
Lamprou, Dimitrios A.
author_facet Basile, Sara
Mathew, Essyrose
Genta, Ida
Conti, Bice
Dorati, Rossella
Lamprou, Dimitrios A.
author_sort Basile, Sara
collection PubMed
description 3D printing has provided a new prospective in the manufacturing of personalized medical implants, including fistulas for haemodialysis (HD). In the current study, an optimized fused modelling deposition (FDM) 3D printing method has been validated, for the first time, to obtain cylindrical shaped fistulas. Printing parameters were evaluated for the manufacturing of fistulas using blank and 0.25% curcumin-loaded filaments that were produced by hot melt extrusion (HME). Four different fistula types have been designed and characterized using a variety of physicochemical characterization methods. Each design was printed three times to demonstrate printing process accuracy considering outer and inner diameter, wall thickness, width, and length. A thermoplastic polyurethane (TPU) biocompatible elastomer was chosen, showing good mechanical properties with a high elastic modulus and maximum elongation, as well as stability at high temperatures with less than 0.8% of degradation at the range between 25 and 250 °C. Curcumin release profile has been evaluated in a saline buffer, obtaining a low release (12%) and demonstrating drug could continue release for a longer period, and for as long as grafts should remain in patient body. Possibility to produce drug-loaded grafts using one-step method as well as 3D printing process and TPU filaments containing curcumin printability has been demonstrated. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-103153502023-07-04 Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts Basile, Sara Mathew, Essyrose Genta, Ida Conti, Bice Dorati, Rossella Lamprou, Dimitrios A. Drug Deliv Transl Res Original Article 3D printing has provided a new prospective in the manufacturing of personalized medical implants, including fistulas for haemodialysis (HD). In the current study, an optimized fused modelling deposition (FDM) 3D printing method has been validated, for the first time, to obtain cylindrical shaped fistulas. Printing parameters were evaluated for the manufacturing of fistulas using blank and 0.25% curcumin-loaded filaments that were produced by hot melt extrusion (HME). Four different fistula types have been designed and characterized using a variety of physicochemical characterization methods. Each design was printed three times to demonstrate printing process accuracy considering outer and inner diameter, wall thickness, width, and length. A thermoplastic polyurethane (TPU) biocompatible elastomer was chosen, showing good mechanical properties with a high elastic modulus and maximum elongation, as well as stability at high temperatures with less than 0.8% of degradation at the range between 25 and 250 °C. Curcumin release profile has been evaluated in a saline buffer, obtaining a low release (12%) and demonstrating drug could continue release for a longer period, and for as long as grafts should remain in patient body. Possibility to produce drug-loaded grafts using one-step method as well as 3D printing process and TPU filaments containing curcumin printability has been demonstrated. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2021-10-12 2023 /pmc/articles/PMC10315350/ /pubmed/34642844 http://dx.doi.org/10.1007/s13346-021-01078-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Basile, Sara
Mathew, Essyrose
Genta, Ida
Conti, Bice
Dorati, Rossella
Lamprou, Dimitrios A.
Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts
title Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts
title_full Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts
title_fullStr Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts
title_full_unstemmed Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts
title_short Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts
title_sort optimization of fdm 3d printing process parameters to produce haemodialysis curcumin-loaded vascular grafts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315350/
https://www.ncbi.nlm.nih.gov/pubmed/34642844
http://dx.doi.org/10.1007/s13346-021-01078-2
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