Multifocal osteomyelitis in a child with sickle cell disease and review of the literature regarding best diagnostic approach

KEY CLINICAL MESSAGE: In patients with sickle cell disease, we must be more cognizant of the possibility of multifocal osteomyelitis. Diagnosis can be challenging in this patient population as the symptoms mimic vaso‐occlusive crisis. There is no gold standard in imaging. ABSTRACT: Osteomyelitis occurs more frequently in children with sickle cell disease. Diagnosis is challenging as it mimics vaso‐occlusive crises, a common manifestation of sickle cell disease. We present a case of a 22‐month‐old girl with sickle cell disease and multifocal osteomyelitis. We review the literature on the utility of diagnostic imaging.