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Restless leg syndrome in multiple sclerosis: a case–control study

OBJECTIVES: This study assessed the prevalence of restless leg syndrome (RLS) among patients with multiple sclerosis (pwMS) and the association between RLS and MS disease duration, sleep disturbance, and daytime fatigue. METHODS: In this cross-sectional study, we interviewed 123 patients via phone c...

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Autores principales: Aljarallah, Salman, Alkhawajah, Nuha, Aldosari, Omar, Alhuqbani, Mohammed, Alqifari, Faisal, Alkhuwaitir, Bassam, Aldawood, Abdullah, Alshenawy, Omar, BaHammam, Ahmed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315471/
https://www.ncbi.nlm.nih.gov/pubmed/37404942
http://dx.doi.org/10.3389/fneur.2023.1194212
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author Aljarallah, Salman
Alkhawajah, Nuha
Aldosari, Omar
Alhuqbani, Mohammed
Alqifari, Faisal
Alkhuwaitir, Bassam
Aldawood, Abdullah
Alshenawy, Omar
BaHammam, Ahmed S.
author_facet Aljarallah, Salman
Alkhawajah, Nuha
Aldosari, Omar
Alhuqbani, Mohammed
Alqifari, Faisal
Alkhuwaitir, Bassam
Aldawood, Abdullah
Alshenawy, Omar
BaHammam, Ahmed S.
author_sort Aljarallah, Salman
collection PubMed
description OBJECTIVES: This study assessed the prevalence of restless leg syndrome (RLS) among patients with multiple sclerosis (pwMS) and the association between RLS and MS disease duration, sleep disturbance, and daytime fatigue. METHODS: In this cross-sectional study, we interviewed 123 patients via phone calls using preset questionnaires containing the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria, Pittsburgh Sleep Quality Index (PSQI), and Fatigue Severity Scale (FSS) diagnostic criteria validated in both Arabic and English. The prevalence of RLS in MS was compared to a group of healthy controls. RESULTS: The prevalence of RLS in pwMS, defined by meeting all four requirements included in the IRLSSG diagnostic criteria, was 30.3% compared to 8.3% in the control group. About 27.3% had mild RLS, 36.4% presented with moderate, and the remaining had severe or very severe symptoms. Patients with MS who experience RLS had a 2.8 times higher risk of fatigue compared to pwMS without RLS. pwMS with RLS had worse sleep quality, with a mean difference of 0.64 in the global PSQI score. Sleep disturbance and latency had the most significant impact on sleep quality. CONCLUSION: The prevalence of RLS among MS patients was significantly higher compared to the control group. We recommend educating neurologists and general physicians to increase their awareness of the increasing prevalence of RLS and its association with fatigue and sleep disturbance in patients with MS.
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spelling pubmed-103154712023-07-04 Restless leg syndrome in multiple sclerosis: a case–control study Aljarallah, Salman Alkhawajah, Nuha Aldosari, Omar Alhuqbani, Mohammed Alqifari, Faisal Alkhuwaitir, Bassam Aldawood, Abdullah Alshenawy, Omar BaHammam, Ahmed S. Front Neurol Neurology OBJECTIVES: This study assessed the prevalence of restless leg syndrome (RLS) among patients with multiple sclerosis (pwMS) and the association between RLS and MS disease duration, sleep disturbance, and daytime fatigue. METHODS: In this cross-sectional study, we interviewed 123 patients via phone calls using preset questionnaires containing the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria, Pittsburgh Sleep Quality Index (PSQI), and Fatigue Severity Scale (FSS) diagnostic criteria validated in both Arabic and English. The prevalence of RLS in MS was compared to a group of healthy controls. RESULTS: The prevalence of RLS in pwMS, defined by meeting all four requirements included in the IRLSSG diagnostic criteria, was 30.3% compared to 8.3% in the control group. About 27.3% had mild RLS, 36.4% presented with moderate, and the remaining had severe or very severe symptoms. Patients with MS who experience RLS had a 2.8 times higher risk of fatigue compared to pwMS without RLS. pwMS with RLS had worse sleep quality, with a mean difference of 0.64 in the global PSQI score. Sleep disturbance and latency had the most significant impact on sleep quality. CONCLUSION: The prevalence of RLS among MS patients was significantly higher compared to the control group. We recommend educating neurologists and general physicians to increase their awareness of the increasing prevalence of RLS and its association with fatigue and sleep disturbance in patients with MS. Frontiers Media S.A. 2023-06-19 /pmc/articles/PMC10315471/ /pubmed/37404942 http://dx.doi.org/10.3389/fneur.2023.1194212 Text en Copyright © 2023 Aljarallah, Alkhawajah, Aldosari, Alhuqbani, Alqifari, Alkhuwaitir, Aldawood, Alshenawy and BaHammam. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Aljarallah, Salman
Alkhawajah, Nuha
Aldosari, Omar
Alhuqbani, Mohammed
Alqifari, Faisal
Alkhuwaitir, Bassam
Aldawood, Abdullah
Alshenawy, Omar
BaHammam, Ahmed S.
Restless leg syndrome in multiple sclerosis: a case–control study
title Restless leg syndrome in multiple sclerosis: a case–control study
title_full Restless leg syndrome in multiple sclerosis: a case–control study
title_fullStr Restless leg syndrome in multiple sclerosis: a case–control study
title_full_unstemmed Restless leg syndrome in multiple sclerosis: a case–control study
title_short Restless leg syndrome in multiple sclerosis: a case–control study
title_sort restless leg syndrome in multiple sclerosis: a case–control study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315471/
https://www.ncbi.nlm.nih.gov/pubmed/37404942
http://dx.doi.org/10.3389/fneur.2023.1194212
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