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FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function

Sleep and circadian rhythms are observed broadly throughout animal phyla and influence neural plasticity and cognitive function. However, the few phylogenetically conserved cellular and molecular pathways that are implicated in these processes are largely focused on neuronal cells. Research on these...

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Autores principales: Gerstner, Jason R., Flores, Carlos C., Lefton, Micah, Rogers, Brooke, Davis, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315501/
https://www.ncbi.nlm.nih.gov/pubmed/37404868
http://dx.doi.org/10.3389/fnsys.2023.1212213
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author Gerstner, Jason R.
Flores, Carlos C.
Lefton, Micah
Rogers, Brooke
Davis, Christopher J.
author_facet Gerstner, Jason R.
Flores, Carlos C.
Lefton, Micah
Rogers, Brooke
Davis, Christopher J.
author_sort Gerstner, Jason R.
collection PubMed
description Sleep and circadian rhythms are observed broadly throughout animal phyla and influence neural plasticity and cognitive function. However, the few phylogenetically conserved cellular and molecular pathways that are implicated in these processes are largely focused on neuronal cells. Research on these topics has traditionally segregated sleep homeostatic behavior from circadian rest-activity rhythms. Here we posit an alternative perspective, whereby mechanisms underlying the integration of sleep and circadian rhythms that affect behavioral state, plasticity, and cognition reside within glial cells. The brain-type fatty acid binding protein, FABP7, is part of a larger family of lipid chaperone proteins that regulate the subcellular trafficking of fatty acids for a wide range of cellular functions, including gene expression, growth, survival, inflammation, and metabolism. FABP7 is enriched in glial cells of the central nervous system and has been shown to be a clock-controlled gene implicated in sleep/wake regulation and cognitive processing. FABP7 is known to affect gene transcription, cellular outgrowth, and its subcellular localization in the fine perisynaptic astrocytic processes (PAPs) varies based on time-of-day. Future studies determining the effects of FABP7 on behavioral state- and circadian-dependent plasticity and cognitive processes, in addition to functional consequences on cellular and molecular mechanisms related to neural-glial interactions, lipid storage, and blood brain barrier integrity will be important for our knowledge of basic sleep function. Given the comorbidity of sleep disturbance with neurological disorders, these studies will also be important for our understanding of the etiology and pathophysiology of how these diseases affect or are affected by sleep.
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spelling pubmed-103155012023-07-04 FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function Gerstner, Jason R. Flores, Carlos C. Lefton, Micah Rogers, Brooke Davis, Christopher J. Front Syst Neurosci Neuroscience Sleep and circadian rhythms are observed broadly throughout animal phyla and influence neural plasticity and cognitive function. However, the few phylogenetically conserved cellular and molecular pathways that are implicated in these processes are largely focused on neuronal cells. Research on these topics has traditionally segregated sleep homeostatic behavior from circadian rest-activity rhythms. Here we posit an alternative perspective, whereby mechanisms underlying the integration of sleep and circadian rhythms that affect behavioral state, plasticity, and cognition reside within glial cells. The brain-type fatty acid binding protein, FABP7, is part of a larger family of lipid chaperone proteins that regulate the subcellular trafficking of fatty acids for a wide range of cellular functions, including gene expression, growth, survival, inflammation, and metabolism. FABP7 is enriched in glial cells of the central nervous system and has been shown to be a clock-controlled gene implicated in sleep/wake regulation and cognitive processing. FABP7 is known to affect gene transcription, cellular outgrowth, and its subcellular localization in the fine perisynaptic astrocytic processes (PAPs) varies based on time-of-day. Future studies determining the effects of FABP7 on behavioral state- and circadian-dependent plasticity and cognitive processes, in addition to functional consequences on cellular and molecular mechanisms related to neural-glial interactions, lipid storage, and blood brain barrier integrity will be important for our knowledge of basic sleep function. Given the comorbidity of sleep disturbance with neurological disorders, these studies will also be important for our understanding of the etiology and pathophysiology of how these diseases affect or are affected by sleep. Frontiers Media S.A. 2023-06-19 /pmc/articles/PMC10315501/ /pubmed/37404868 http://dx.doi.org/10.3389/fnsys.2023.1212213 Text en Copyright © 2023 Gerstner, Flores, Lefton, Rogers and Davis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gerstner, Jason R.
Flores, Carlos C.
Lefton, Micah
Rogers, Brooke
Davis, Christopher J.
FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function
title FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function
title_full FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function
title_fullStr FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function
title_full_unstemmed FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function
title_short FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function
title_sort fabp7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315501/
https://www.ncbi.nlm.nih.gov/pubmed/37404868
http://dx.doi.org/10.3389/fnsys.2023.1212213
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