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Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football

INTRODUCTION: We examined postmortem brain tissue from men, over the age of 50, for chronic traumatic encephalopathy neuropathologic change (CTE-NC). We hypothesized that (i) a small percentage would have CTE-NC, (ii) those who played American football during their youth would be more likely to have...

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Autores principales: Iverson, Grant L., Jamshidi, Pouya, Fisher-Hubbard, Amanda O., Deep-Soboslay, Amy, Hyde, Thomas M., Kleinman, Joel E., deJong, Joyce L., Shepherd, Claire E., Hazrati, Lili-Naz, Castellani, Rudolph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315537/
https://www.ncbi.nlm.nih.gov/pubmed/37404944
http://dx.doi.org/10.3389/fneur.2023.1143882
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author Iverson, Grant L.
Jamshidi, Pouya
Fisher-Hubbard, Amanda O.
Deep-Soboslay, Amy
Hyde, Thomas M.
Kleinman, Joel E.
deJong, Joyce L.
Shepherd, Claire E.
Hazrati, Lili-Naz
Castellani, Rudolph J.
author_facet Iverson, Grant L.
Jamshidi, Pouya
Fisher-Hubbard, Amanda O.
Deep-Soboslay, Amy
Hyde, Thomas M.
Kleinman, Joel E.
deJong, Joyce L.
Shepherd, Claire E.
Hazrati, Lili-Naz
Castellani, Rudolph J.
author_sort Iverson, Grant L.
collection PubMed
description INTRODUCTION: We examined postmortem brain tissue from men, over the age of 50, for chronic traumatic encephalopathy neuropathologic change (CTE-NC). We hypothesized that (i) a small percentage would have CTE-NC, (ii) those who played American football during their youth would be more likely to have CTE-NC than those who did not play contact or collision sports, and (iii) there would be no association between CTE-NC and suicide as a manner of death. METHODS: Brain tissue from 186 men and accompanying clinical information were obtained from the Lieber Institute for Brain Development. Manner of death was determined by a board-certified forensic pathologist. Information was obtained from next of kin telephone interviews, including medical, social, demographic, family, and psychiatric history. The 2016 and 2021 consensus definitions were used for CTE-NC. Two authors screened all cases, using liberal criteria for identifying “possible” CTE-NC, and five authors examined the 15 selected cases. RESULTS: The median age at the time of death was 65 years (interquartile range = 57–75; range = 50–96). There were 25.8% with a history of playing American football and 36.0% who had suicide as their manner of death. No case was rated as definitively having “features” of CTE-NC by all five authors. Ten cases were rated as having features of CTE-NC by three or more authors (5.4% of the sample), including 8.3% of those with a personal history of playing American football and 3.9% of those who did not play contact or collision sports. Of those with mood disorders during life, 5.5% had features of CTE-NC compared to 6.0% of those who did not have a reported mood disorder. Of those with suicide as a manner of death, 6.0% had features of CTE-NC compared to 5.0% of those who did not have suicide as a manner of death. DISCUSSION: We did not identify a single definitive case of CTE-NC, from the perspective of all raters, and only 5.4% of cases were identified as having possible features of CTE-NC by some raters. CTE-NC was very uncommon in men who played amateur American football, those with mood disorders during life, and those with suicide as a manner of death.
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spelling pubmed-103155372023-07-04 Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football Iverson, Grant L. Jamshidi, Pouya Fisher-Hubbard, Amanda O. Deep-Soboslay, Amy Hyde, Thomas M. Kleinman, Joel E. deJong, Joyce L. Shepherd, Claire E. Hazrati, Lili-Naz Castellani, Rudolph J. Front Neurol Neurology INTRODUCTION: We examined postmortem brain tissue from men, over the age of 50, for chronic traumatic encephalopathy neuropathologic change (CTE-NC). We hypothesized that (i) a small percentage would have CTE-NC, (ii) those who played American football during their youth would be more likely to have CTE-NC than those who did not play contact or collision sports, and (iii) there would be no association between CTE-NC and suicide as a manner of death. METHODS: Brain tissue from 186 men and accompanying clinical information were obtained from the Lieber Institute for Brain Development. Manner of death was determined by a board-certified forensic pathologist. Information was obtained from next of kin telephone interviews, including medical, social, demographic, family, and psychiatric history. The 2016 and 2021 consensus definitions were used for CTE-NC. Two authors screened all cases, using liberal criteria for identifying “possible” CTE-NC, and five authors examined the 15 selected cases. RESULTS: The median age at the time of death was 65 years (interquartile range = 57–75; range = 50–96). There were 25.8% with a history of playing American football and 36.0% who had suicide as their manner of death. No case was rated as definitively having “features” of CTE-NC by all five authors. Ten cases were rated as having features of CTE-NC by three or more authors (5.4% of the sample), including 8.3% of those with a personal history of playing American football and 3.9% of those who did not play contact or collision sports. Of those with mood disorders during life, 5.5% had features of CTE-NC compared to 6.0% of those who did not have a reported mood disorder. Of those with suicide as a manner of death, 6.0% had features of CTE-NC compared to 5.0% of those who did not have suicide as a manner of death. DISCUSSION: We did not identify a single definitive case of CTE-NC, from the perspective of all raters, and only 5.4% of cases were identified as having possible features of CTE-NC by some raters. CTE-NC was very uncommon in men who played amateur American football, those with mood disorders during life, and those with suicide as a manner of death. Frontiers Media S.A. 2023-06-19 /pmc/articles/PMC10315537/ /pubmed/37404944 http://dx.doi.org/10.3389/fneur.2023.1143882 Text en Copyright © 2023 Iverson, Jamshidi, Fisher-Hubbard, Deep-Soboslay, Hyde, Kleinman, deJong, Shepherd, Hazrati and Castellani. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Iverson, Grant L.
Jamshidi, Pouya
Fisher-Hubbard, Amanda O.
Deep-Soboslay, Amy
Hyde, Thomas M.
Kleinman, Joel E.
deJong, Joyce L.
Shepherd, Claire E.
Hazrati, Lili-Naz
Castellani, Rudolph J.
Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football
title Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football
title_full Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football
title_fullStr Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football
title_full_unstemmed Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football
title_short Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football
title_sort chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur american football
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315537/
https://www.ncbi.nlm.nih.gov/pubmed/37404944
http://dx.doi.org/10.3389/fneur.2023.1143882
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