Activation of ryanodine-sensitive calcium store drives pseudo-allergic dermatitis via Mas-related G protein-coupled receptor X2 in mast cells

Mast cell (MC) activation is implicated in the pathogenesis of multiple immunodysregulatory skin disorders. Activation of an IgE-independent pseudo-allergic route has been recently found to be mainly mediated via Mas-Related G protein-coupled receptor X2 (MRGPRX2). Ryanodine receptor (RYR) regulates...

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Detalles Bibliográficos
Autores principales: Wang, Zhao, Zhao, Xi, Zhou, Hongmei, Che, Delu, Du, Xiaojie, Ye, Dan, Zeng, Weihui, Geng, Songmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315577/
https://www.ncbi.nlm.nih.gov/pubmed/37404822
http://dx.doi.org/10.3389/fimmu.2023.1207249

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