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Potential biomarkers for the early detection of bone metastases

The clinical manifestations of bone metastases are diversified while many sites remain asymptomatic at early stage. As the early diagnosis method is not perfect and the early symptoms of tumor bone metastasis are not typical, bone metastasis is not easy to be detected. Therefore, the search for bone...

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Autores principales: Hao, Yang, Zhang, Feifan, Ma, Yan, Luo, Yage, Zhang, Yongyong, Yang, Ning, Liu, Man, Liu, Hongjian, Li, Jitian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315674/
https://www.ncbi.nlm.nih.gov/pubmed/37404755
http://dx.doi.org/10.3389/fonc.2023.1188357
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author Hao, Yang
Zhang, Feifan
Ma, Yan
Luo, Yage
Zhang, Yongyong
Yang, Ning
Liu, Man
Liu, Hongjian
Li, Jitian
author_facet Hao, Yang
Zhang, Feifan
Ma, Yan
Luo, Yage
Zhang, Yongyong
Yang, Ning
Liu, Man
Liu, Hongjian
Li, Jitian
author_sort Hao, Yang
collection PubMed
description The clinical manifestations of bone metastases are diversified while many sites remain asymptomatic at early stage. As the early diagnosis method is not perfect and the early symptoms of tumor bone metastasis are not typical, bone metastasis is not easy to be detected. Therefore, the search for bone metastasis-related markers is effective for timely detection of tumor bone metastases and the development of drugs to inhibit bone metastases. As a result, bone metastases can only be diagnosed when symptoms are found, increasing the risk of developing skeletal-related event (SREs), which significantly impairs the patient’s quality of life. Therefore, the early diagnosis of bone metastases is of great importance for the treatment and prognosis of cancer patients. Changes of bone metabolism indexes appear earlier in bone metastases, but the traditional biochemical indexes of bone metabolism lack of specificity and could be interfered by many factors, which limits their application in the study of bone metastases. Some new biomarkers of bone metastases have good diagnostic value, such as proteins, ncRNAs, circulating tumor cells (CTCs). Therefore, this study mainly reviewed the initial diagnostic biomarkers of bone metastases which were expected to provide references for the early detection of bone metastases.
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spelling pubmed-103156742023-07-04 Potential biomarkers for the early detection of bone metastases Hao, Yang Zhang, Feifan Ma, Yan Luo, Yage Zhang, Yongyong Yang, Ning Liu, Man Liu, Hongjian Li, Jitian Front Oncol Oncology The clinical manifestations of bone metastases are diversified while many sites remain asymptomatic at early stage. As the early diagnosis method is not perfect and the early symptoms of tumor bone metastasis are not typical, bone metastasis is not easy to be detected. Therefore, the search for bone metastasis-related markers is effective for timely detection of tumor bone metastases and the development of drugs to inhibit bone metastases. As a result, bone metastases can only be diagnosed when symptoms are found, increasing the risk of developing skeletal-related event (SREs), which significantly impairs the patient’s quality of life. Therefore, the early diagnosis of bone metastases is of great importance for the treatment and prognosis of cancer patients. Changes of bone metabolism indexes appear earlier in bone metastases, but the traditional biochemical indexes of bone metabolism lack of specificity and could be interfered by many factors, which limits their application in the study of bone metastases. Some new biomarkers of bone metastases have good diagnostic value, such as proteins, ncRNAs, circulating tumor cells (CTCs). Therefore, this study mainly reviewed the initial diagnostic biomarkers of bone metastases which were expected to provide references for the early detection of bone metastases. Frontiers Media S.A. 2023-06-19 /pmc/articles/PMC10315674/ /pubmed/37404755 http://dx.doi.org/10.3389/fonc.2023.1188357 Text en Copyright © 2023 Hao, Zhang, Ma, Luo, Zhang, Yang, Liu, Liu and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Hao, Yang
Zhang, Feifan
Ma, Yan
Luo, Yage
Zhang, Yongyong
Yang, Ning
Liu, Man
Liu, Hongjian
Li, Jitian
Potential biomarkers for the early detection of bone metastases
title Potential biomarkers for the early detection of bone metastases
title_full Potential biomarkers for the early detection of bone metastases
title_fullStr Potential biomarkers for the early detection of bone metastases
title_full_unstemmed Potential biomarkers for the early detection of bone metastases
title_short Potential biomarkers for the early detection of bone metastases
title_sort potential biomarkers for the early detection of bone metastases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315674/
https://www.ncbi.nlm.nih.gov/pubmed/37404755
http://dx.doi.org/10.3389/fonc.2023.1188357
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