Multi‐omic analysis in normal colon organoids highlights MSH4 as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability

INTRODUCTION: Lynch syndrome (LS) is a hereditary condition that increases the risk of colorectal (CRC) and extracolonic cancers that exhibit microsatellite instability (MSI‐H). MSI‐H is driven by defective mismatch repair (dMMR), and approximately 15% of nonhereditary CRCs also exhibit MSI‐H. Here,...

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Detalles Bibliográficos
Autores principales: Devall, Matthew, Ali, Mourad W., Eaton, Stephen, Weisenberger, Daniel J., Reilley, Matthew J., Powell, Steven M., Li, Li, Casey, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315803/
https://www.ncbi.nlm.nih.gov/pubmed/37162286
http://dx.doi.org/10.1002/cam4.6048

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