Cargando…

Transcriptomic evidence for tumor‐specific beneficial or adverse effects of TGFβ pathway inhibition on the prognosis of patients with liver cancer

Therapeutic targeting of the transforming growth factor beta (TGFβ) pathway in cancer represents a clinical challenge since TGFβ exhibits either tumor suppressive or tumor promoting properties, depending on the tumor stage. Thus, treatment with galunisertib, a small molecule inhibitor of TGFβ recept...

Descripción completa

Detalles Bibliográficos
Autores principales:	Desoteux, Matthis, Maillot, Betty, Bévant, Kevin, Ferlier, Tanguy, Leroux, Raffaële, Angenard, Gaëlle, Louis, Corentin, Sulpice, Laurent, Boudjema, Karim, Coulouarn, Cédric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315808/ https://www.ncbi.nlm.nih.gov/pubmed/37195148 http://dx.doi.org/10.1002/2211-5463.13647

Ejemplares similares

TGFβ‐induced FOXS1 controls epithelial–mesenchymal transition and predicts a poor prognosis in liver cancer
por: Bévant, Kevin, et al.
Publicado: (2021)

TGFβ-induced circLTBP2 predicts a poor prognosis in intrahepatic cholangiocarcinoma and mediates gemcitabine resistance by sponging miR-338-3p
por: Louis, Corentin, et al.
Publicado: (2023)

A Minimal Subset of Seven Genes Associated with Tumor Hepatocyte Differentiation Predicts a Poor Prognosis in Human Hepatocellular Carcinoma
por: Desoteux, Matthis, et al.
Publicado: (2021)

DNA Methylation of TGFβ Target Genes: Epigenetic Control of TGFβ Functional Duality in Liver Cancer
por: Bévant, Kevin, et al.
Publicado: (2021)

Molecular profiling of stroma highlights stratifin as a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma
por: Robin, Fabien, et al.
Publicado: (2020)

Regulation of Gene Expression in Cancer—An Overview
por: Ferlier, Tanguy, et al.
Publicado: (2022)

A novel transforming growth factor beta‐induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma
por: Merdrignac, Aude, et al.
Publicado: (2018)

Gene expression profiling of the tumor microenvironment in human intrahepatic cholangiocarcinoma
por: Sulpice, Laurent, et al.
Publicado: (2016)

A novel immunosuppression-based classification of liver tumors opens new perspectives for adapted therapeutic strategies
por: Bévant, Kevin, et al.
Publicado: (2020)

Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma
por: Papoutsoglou, Panagiotis, et al.
Publicado: (2019)

The Role of Cavoportal and Renoportal Hemitransposition in Liver Transplantation
por: Maillot, Betty, et al.
Publicado: (2022)

Emerging roles of circular RNAs in liver cancer
por: Louis, Corentin, et al.
Publicado: (2021)

Influence of Hemorrhagic Complications of Pancreatoduodenectomy in Patients with Cancer on Short- and Long-Term Mortality
por: Thobie, Alexandre, et al.
Publicado: (2023)

The Consumption of Cholesterol-Enriched Diets Conditions the Development of a Subtype of HCC with High Aggressiveness and Poor Prognosis
por: Simoni-Nieves, Arturo, et al.
Publicado: (2021)

Liver Resection for Type IV Perihilar Cholangiocarcinoma: Left or Right Trisectionectomy?
por: Jeddou, Heithem, et al.
Publicado: (2022)

TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
por: Dropmann, Anne, et al.
Publicado: (2016)

Comparative Analysis of TGF-β/Smad Signaling Dependent Cytostasis in Human Hepatocellular Carcinoma Cell Lines
por: Dzieran, Johanna, et al.
Publicado: (2013)

SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance
por: Yuan, Xiaodong, et al.
Publicado: (2018)

Research transparency promotion by surgical journals publishing randomised controlled trials: a survey
por: Lombard, N., et al.
Publicado: (2020)

The Molecular Mechanisms Underlying Onset and Progression of Liver Cancers
por: Le Breton, Clara, et al.
Publicado: (2023)

Beneficial and adverse effects of vitamin E on the kidney
por: Baltusnikiene, Aldona, et al.
Publicado: (2023)

The Beneficial and Adverse Effects of Autophagic Response to Caloric Restriction and Fasting
por: Shabkhizan, Roya, et al.
Publicado: (2023)

De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas
por: Mebarki, Sihem, et al.
Publicado: (2016)

The Beneficial and Adverse Effects of Raloxifene in Menopausal Women: A Mini Review
por: Khorsand, Imaneh, et al.
Publicado: (2018)

Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects?
por: Lecomte, Sylvain, et al.
Publicado: (2017)

Consumption of Maternal Placenta in Humans and Nonhuman Mammals: Beneficial and Adverse Effects
por: Mota-Rojas, Daniel, et al.
Publicado: (2020)

The adverse and beneficial effects of polyphenols in green and black teas in vitro and in vivo
por: Wu, Mei-Hui, et al.
Publicado: (2023)

Beneficial and Adverse Effects of Bosentan Treatment in Korean Patients With Pulmonary Artery Hypertension
por: Sohn, Dae-Won, et al.
Publicado: (2009)

Cadmium Increases Human Fetal Germ Cell Apoptosis
por: Angenard, Gaëlle, et al.
Publicado: (2010)

R1 Vascular or Parenchymal Margins: What Is the Impact after Resection of Intrahepatic Cholangiocarcinoma?
por: Mabilia, Andrea, et al.
Publicado: (2022)

TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis
por: Varricchio, Lilian, et al.
Publicado: (2021)

Phthalates Impair Germ Cell Development in the Human Fetal Testis in Vitro without Change in Testosterone Production
por: Lambrot, Romain, et al.
Publicado: (2009)

Surgical resection for liver cancer during the COVID-19 outbreak
por: Triki, Haitham, et al.
Publicado: (2020)

The Unexpected Effects of Beneficial and Adverse Social Experiences during Adolescence on Anxiety and Aggression and Their Modulation by Genotype
por: Meyer, Neele, et al.
Publicado: (2016)

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function
por: Lundgaard, Iben, et al.
Publicado: (2018)

The Impact of Immune Interventions: A Systems Biology Strategy for Predicting Adverse and Beneficial Immune Effects
por: Meijerink, Marjolein, et al.
Publicado: (2019)

Estimation of individual beneficial and adverse effects of intensive glucose control for patients with type 2 diabetes
por: van der Leeuw, Joep, et al.
Publicado: (2016)

Dynamics of beneficial epidemics
por: Berdahl, Andrew, et al.
Publicado: (2019)

An α2-Adrenergic Agonist, Brimonidine, Beneficially Affects the TGF-β2-Treated Cellular Properties in an In Vitro Culture Model
por: Watanabe, Megumi, et al.
Publicado: (2022)

Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects
por: Pall, Martin L
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7664at3el6v3gg31t72km6ttnt