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Urethral discharge as an early manifestation of urinary tract infection in children ≤24 months old

BACKGROUND: Children with febrile urinary tract infections (UTIs) are prone to kidney scarring if they are not treated promptly; however, ambiguous symptoms before fever onset makes the early detection of UTIs difficult. Our study aimed to identify urethral discharge as an early manifestation in chi...

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Autores principales: Fang, Nai-Wen, Ou, Shih-Hsiang, Huang, Yu-Shan, Chiou, Yee-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315818/
https://www.ncbi.nlm.nih.gov/pubmed/37404552
http://dx.doi.org/10.3389/fped.2023.1149218
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author Fang, Nai-Wen
Ou, Shih-Hsiang
Huang, Yu-Shan
Chiou, Yee-Hsuan
author_facet Fang, Nai-Wen
Ou, Shih-Hsiang
Huang, Yu-Shan
Chiou, Yee-Hsuan
author_sort Fang, Nai-Wen
collection PubMed
description BACKGROUND: Children with febrile urinary tract infections (UTIs) are prone to kidney scarring if they are not treated promptly; however, ambiguous symptoms before fever onset makes the early detection of UTIs difficult. Our study aimed to identify urethral discharge as an early manifestation in children with UTI. METHODS: This study enrolled 678 children younger than 24 months with paired urinalysis and culture performed between 2015 and 2021; 544 children were diagnosed with UTIs. Clinical symptoms, urinalysis, and paired urine culture results were compared. RESULTS: Urethral discharge was observed in 5.1% of children with UTI and yielded a specificity of 92.5% for diagnosing UTI. Children with urethral discharge had a less severe UTI course, furthermore, nine of them received antibiotics before fever occurred and seven of them were free of fever during UTI course. Urethral discharge was associated with alkalotic urine and Klebsiella pneumonia infection. CONCLUSIONS: Urethral discharge is an early symptom in children with UTI; it may present before fever onset and help ensure prompt antibiotic intervention.
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spelling pubmed-103158182023-07-04 Urethral discharge as an early manifestation of urinary tract infection in children ≤24 months old Fang, Nai-Wen Ou, Shih-Hsiang Huang, Yu-Shan Chiou, Yee-Hsuan Front Pediatr Pediatrics BACKGROUND: Children with febrile urinary tract infections (UTIs) are prone to kidney scarring if they are not treated promptly; however, ambiguous symptoms before fever onset makes the early detection of UTIs difficult. Our study aimed to identify urethral discharge as an early manifestation in children with UTI. METHODS: This study enrolled 678 children younger than 24 months with paired urinalysis and culture performed between 2015 and 2021; 544 children were diagnosed with UTIs. Clinical symptoms, urinalysis, and paired urine culture results were compared. RESULTS: Urethral discharge was observed in 5.1% of children with UTI and yielded a specificity of 92.5% for diagnosing UTI. Children with urethral discharge had a less severe UTI course, furthermore, nine of them received antibiotics before fever occurred and seven of them were free of fever during UTI course. Urethral discharge was associated with alkalotic urine and Klebsiella pneumonia infection. CONCLUSIONS: Urethral discharge is an early symptom in children with UTI; it may present before fever onset and help ensure prompt antibiotic intervention. Frontiers Media S.A. 2023-06-19 /pmc/articles/PMC10315818/ /pubmed/37404552 http://dx.doi.org/10.3389/fped.2023.1149218 Text en © 2023 Fang, Ou, Huang and Chiou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Fang, Nai-Wen
Ou, Shih-Hsiang
Huang, Yu-Shan
Chiou, Yee-Hsuan
Urethral discharge as an early manifestation of urinary tract infection in children ≤24 months old
title Urethral discharge as an early manifestation of urinary tract infection in children ≤24 months old
title_full Urethral discharge as an early manifestation of urinary tract infection in children ≤24 months old
title_fullStr Urethral discharge as an early manifestation of urinary tract infection in children ≤24 months old
title_full_unstemmed Urethral discharge as an early manifestation of urinary tract infection in children ≤24 months old
title_short Urethral discharge as an early manifestation of urinary tract infection in children ≤24 months old
title_sort urethral discharge as an early manifestation of urinary tract infection in children ≤24 months old
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315818/
https://www.ncbi.nlm.nih.gov/pubmed/37404552
http://dx.doi.org/10.3389/fped.2023.1149218
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