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Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma

Superficial CD34 positive fibroblastic tumor is a rare low-grade neoplasm of the skin and subcutis with indolent behavior. This entity has been included in the current World Health Organisation (WHO) classification of soft tissue tumors. Pathological diagnosis can be challenging due to significant m...

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Detalles Bibliográficos
Autores principales: Bruce-Brand, Cassandra, Conradie, Wilhelmina, Schneider, Johann W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315862/
https://www.ncbi.nlm.nih.gov/pubmed/36221951
http://dx.doi.org/10.1177/10668969221126109
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author Bruce-Brand, Cassandra
Conradie, Wilhelmina
Schneider, Johann W
author_facet Bruce-Brand, Cassandra
Conradie, Wilhelmina
Schneider, Johann W
author_sort Bruce-Brand, Cassandra
collection PubMed
description Superficial CD34 positive fibroblastic tumor is a rare low-grade neoplasm of the skin and subcutis with indolent behavior. This entity has been included in the current World Health Organisation (WHO) classification of soft tissue tumors. Pathological diagnosis can be challenging due to significant morphological overlap with other entities and the large spectrum of CD34 positive tumors. We report a case in a twenty-five male which showed characteristic diagnostic features, but in addition showed myxoid stroma. The presence of myxoid stroma has not been previously emphasized in this entity and broadens the histologic differential diagnosis significantly to include myxoid soft tissue tumors. A subset of these tumors harbor PRDM10-rearrangements, but a defining molecular feature has not yet been described, highlighting the need for further molecular characterization of this potentially genetically heterogenous tumor. Awareness of this entity among surgeons and pathologists is important to prevent misclassification as an aggressive sarcoma and avoid over-treatment.
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spelling pubmed-103158622023-07-04 Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma Bruce-Brand, Cassandra Conradie, Wilhelmina Schneider, Johann W Int J Surg Pathol Case Reports Superficial CD34 positive fibroblastic tumor is a rare low-grade neoplasm of the skin and subcutis with indolent behavior. This entity has been included in the current World Health Organisation (WHO) classification of soft tissue tumors. Pathological diagnosis can be challenging due to significant morphological overlap with other entities and the large spectrum of CD34 positive tumors. We report a case in a twenty-five male which showed characteristic diagnostic features, but in addition showed myxoid stroma. The presence of myxoid stroma has not been previously emphasized in this entity and broadens the histologic differential diagnosis significantly to include myxoid soft tissue tumors. A subset of these tumors harbor PRDM10-rearrangements, but a defining molecular feature has not yet been described, highlighting the need for further molecular characterization of this potentially genetically heterogenous tumor. Awareness of this entity among surgeons and pathologists is important to prevent misclassification as an aggressive sarcoma and avoid over-treatment. SAGE Publications 2022-10-11 2023-08 /pmc/articles/PMC10315862/ /pubmed/36221951 http://dx.doi.org/10.1177/10668969221126109 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Bruce-Brand, Cassandra
Conradie, Wilhelmina
Schneider, Johann W
Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma
title Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma
title_full Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma
title_fullStr Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma
title_full_unstemmed Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma
title_short Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma
title_sort superficial cd34 positive fibroblastic tumour with myxoid stroma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315862/
https://www.ncbi.nlm.nih.gov/pubmed/36221951
http://dx.doi.org/10.1177/10668969221126109
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