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Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma
Superficial CD34 positive fibroblastic tumor is a rare low-grade neoplasm of the skin and subcutis with indolent behavior. This entity has been included in the current World Health Organisation (WHO) classification of soft tissue tumors. Pathological diagnosis can be challenging due to significant m...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315862/ https://www.ncbi.nlm.nih.gov/pubmed/36221951 http://dx.doi.org/10.1177/10668969221126109 |
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author | Bruce-Brand, Cassandra Conradie, Wilhelmina Schneider, Johann W |
author_facet | Bruce-Brand, Cassandra Conradie, Wilhelmina Schneider, Johann W |
author_sort | Bruce-Brand, Cassandra |
collection | PubMed |
description | Superficial CD34 positive fibroblastic tumor is a rare low-grade neoplasm of the skin and subcutis with indolent behavior. This entity has been included in the current World Health Organisation (WHO) classification of soft tissue tumors. Pathological diagnosis can be challenging due to significant morphological overlap with other entities and the large spectrum of CD34 positive tumors. We report a case in a twenty-five male which showed characteristic diagnostic features, but in addition showed myxoid stroma. The presence of myxoid stroma has not been previously emphasized in this entity and broadens the histologic differential diagnosis significantly to include myxoid soft tissue tumors. A subset of these tumors harbor PRDM10-rearrangements, but a defining molecular feature has not yet been described, highlighting the need for further molecular characterization of this potentially genetically heterogenous tumor. Awareness of this entity among surgeons and pathologists is important to prevent misclassification as an aggressive sarcoma and avoid over-treatment. |
format | Online Article Text |
id | pubmed-10315862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-103158622023-07-04 Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma Bruce-Brand, Cassandra Conradie, Wilhelmina Schneider, Johann W Int J Surg Pathol Case Reports Superficial CD34 positive fibroblastic tumor is a rare low-grade neoplasm of the skin and subcutis with indolent behavior. This entity has been included in the current World Health Organisation (WHO) classification of soft tissue tumors. Pathological diagnosis can be challenging due to significant morphological overlap with other entities and the large spectrum of CD34 positive tumors. We report a case in a twenty-five male which showed characteristic diagnostic features, but in addition showed myxoid stroma. The presence of myxoid stroma has not been previously emphasized in this entity and broadens the histologic differential diagnosis significantly to include myxoid soft tissue tumors. A subset of these tumors harbor PRDM10-rearrangements, but a defining molecular feature has not yet been described, highlighting the need for further molecular characterization of this potentially genetically heterogenous tumor. Awareness of this entity among surgeons and pathologists is important to prevent misclassification as an aggressive sarcoma and avoid over-treatment. SAGE Publications 2022-10-11 2023-08 /pmc/articles/PMC10315862/ /pubmed/36221951 http://dx.doi.org/10.1177/10668969221126109 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Reports Bruce-Brand, Cassandra Conradie, Wilhelmina Schneider, Johann W Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma |
title | Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma |
title_full | Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma |
title_fullStr | Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma |
title_full_unstemmed | Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma |
title_short | Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma |
title_sort | superficial cd34 positive fibroblastic tumour with myxoid stroma |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315862/ https://www.ncbi.nlm.nih.gov/pubmed/36221951 http://dx.doi.org/10.1177/10668969221126109 |
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