Five new sesquiterpenoids from agarwood of Aquilaria sinensis

Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations, were identified by comprehensive spectroscopic analyses and computational methods. Inspired b...

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Detalles Bibliográficos
Autores principales: Zhou, Hong, Li, Xu-Yang, Fang, Hong-Bin, Jiang, He-Zhong, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315886/
https://www.ncbi.nlm.nih.gov/pubmed/37404799
http://dx.doi.org/10.3762/bjoc.19.75
Descripción
Sumario:Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations, were identified by comprehensive spectroscopic analyses and computational methods. Inspired by our previous study on the same kinds of skeletons, we speculated that the new compounds have anticancer and anti-inflammatory activities. The results did not show any activity, but they revealed the structure–activity relationships (SAR).

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