Five new sesquiterpenoids from agarwood of Aquilaria sinensis

Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations, were identified by comprehensive spectroscopic analyses and computational methods. Inspired b...

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Autores principales: Zhou, Hong, Li, Xu-Yang, Fang, Hong-Bin, Jiang, He-Zhong, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315886/
https://www.ncbi.nlm.nih.gov/pubmed/37404799
http://dx.doi.org/10.3762/bjoc.19.75
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author Zhou, Hong
Li, Xu-Yang
Fang, Hong-Bin
Jiang, He-Zhong
Cheng, Yong-Xian
author_facet Zhou, Hong
Li, Xu-Yang
Fang, Hong-Bin
Jiang, He-Zhong
Cheng, Yong-Xian
author_sort Zhou, Hong
collection PubMed
description Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations, were identified by comprehensive spectroscopic analyses and computational methods. Inspired by our previous study on the same kinds of skeletons, we speculated that the new compounds have anticancer and anti-inflammatory activities. The results did not show any activity, but they revealed the structure–activity relationships (SAR).
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spelling pubmed-103158862023-07-04 Five new sesquiterpenoids from agarwood of Aquilaria sinensis Zhou, Hong Li, Xu-Yang Fang, Hong-Bin Jiang, He-Zhong Cheng, Yong-Xian Beilstein J Org Chem Full Research Paper Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations, were identified by comprehensive spectroscopic analyses and computational methods. Inspired by our previous study on the same kinds of skeletons, we speculated that the new compounds have anticancer and anti-inflammatory activities. The results did not show any activity, but they revealed the structure–activity relationships (SAR). Beilstein-Institut 2023-06-30 /pmc/articles/PMC10315886/ /pubmed/37404799 http://dx.doi.org/10.3762/bjoc.19.75 Text en Copyright © 2023, Zhou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Full Research Paper
Zhou, Hong
Li, Xu-Yang
Fang, Hong-Bin
Jiang, He-Zhong
Cheng, Yong-Xian
Five new sesquiterpenoids from agarwood of Aquilaria sinensis
title Five new sesquiterpenoids from agarwood of Aquilaria sinensis
title_full Five new sesquiterpenoids from agarwood of Aquilaria sinensis
title_fullStr Five new sesquiterpenoids from agarwood of Aquilaria sinensis
title_full_unstemmed Five new sesquiterpenoids from agarwood of Aquilaria sinensis
title_short Five new sesquiterpenoids from agarwood of Aquilaria sinensis
title_sort five new sesquiterpenoids from agarwood of aquilaria sinensis
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315886/
https://www.ncbi.nlm.nih.gov/pubmed/37404799
http://dx.doi.org/10.3762/bjoc.19.75
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