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Regulation of cGAS and STING signaling during inflammation and infection

Stimulator of interferon genes (STING) is a sensor of cyclic dinucleotides including cyclic GMP-AMP, which is produced by cyclic GMP-AMP synthase (cGAS) in response to cytosolic DNA. The cGAS–STING signaling pathway regulates both innate and adaptive immune responses, as well as fundamental cellular...

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Detalles Bibliográficos
Autores principales: Chauvin, Samuel D., Stinson, W. Alexander, Platt, Derek J., Poddar, Subhajit, Miner, Jonathan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316007/
https://www.ncbi.nlm.nih.gov/pubmed/37247757
http://dx.doi.org/10.1016/j.jbc.2023.104866