Cargando…
Organising pneumonia caused by hormone (tamoxifen) therapy after radiotherapy for breast cancer: a case report and review of the literature
BACKGROUND: Five-year treatment with tamoxifen (TAM) has been the traditional standard of care for breast cancer. Organising pneumonia (OP) is a rare but significant complication of radiation therapy for breast cancer. The effect of TAM leading to OP has not yet been clearly documented. CASE DESCRIP...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316100/ https://www.ncbi.nlm.nih.gov/pubmed/37405001 http://dx.doi.org/10.21037/atm-22-5062 |
_version_ | 1785067642318487552 |
---|---|
author | Zhong, Yuting Zhang, Yanjun Liu, Mei Cheng, Liuquan Yang, Junlan Li, Xiru |
author_facet | Zhong, Yuting Zhang, Yanjun Liu, Mei Cheng, Liuquan Yang, Junlan Li, Xiru |
author_sort | Zhong, Yuting |
collection | PubMed |
description | BACKGROUND: Five-year treatment with tamoxifen (TAM) has been the traditional standard of care for breast cancer. Organising pneumonia (OP) is a rare but significant complication of radiation therapy for breast cancer. The effect of TAM leading to OP has not yet been clearly documented. CASE DESCRIPTION: This report describes the case of a 38-year-old female who developed progressive aggravation of round-like patchy bilateral pulmonary infiltrated with a reverse halo sign but without any clinical symptoms 5 months after TAM therapy, following breast-conserving surgery and radiotherapy (RT) for breast carcinoma. A lung biopsy was performed and revealed a histological pattern of OP. TAM therapy was discontinued, and subsequent gradual radiological improvement was observed. As there was no proof for TAM had caused the incident, TAM was re-administrated. Eight months after reinstitution of TAM, the same patchy migratory bilateral pulmonary infiltrated with reverse halo sign was found on chest CT with the patient claiming no discomforts nor any clinical symptoms. The diagnosis of TAM-related OP was made based on the exclusion of other causes and recurrence with the re-administration of TAM. The multidisciplinary team (MDT) concluded that TAM should be withdrawn and a “wait-and-see” approach was taken after a comprehensive assessment, instead of altering the medication or performing prophylactic mastectomy. CONCLUSIONS: The withdrawal and rechallenge of TAM strongly suggest that it may play a role as a cofactor in the occurrence of OP after RT for breast cancer, and RT may also be a cofactor in the occurrence of OP. It is extremely important to be alerted to the possibility of OP after concurrent or sequential hormonal therapy and RT. |
format | Online Article Text |
id | pubmed-10316100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-103161002023-07-04 Organising pneumonia caused by hormone (tamoxifen) therapy after radiotherapy for breast cancer: a case report and review of the literature Zhong, Yuting Zhang, Yanjun Liu, Mei Cheng, Liuquan Yang, Junlan Li, Xiru Ann Transl Med Case Report BACKGROUND: Five-year treatment with tamoxifen (TAM) has been the traditional standard of care for breast cancer. Organising pneumonia (OP) is a rare but significant complication of radiation therapy for breast cancer. The effect of TAM leading to OP has not yet been clearly documented. CASE DESCRIPTION: This report describes the case of a 38-year-old female who developed progressive aggravation of round-like patchy bilateral pulmonary infiltrated with a reverse halo sign but without any clinical symptoms 5 months after TAM therapy, following breast-conserving surgery and radiotherapy (RT) for breast carcinoma. A lung biopsy was performed and revealed a histological pattern of OP. TAM therapy was discontinued, and subsequent gradual radiological improvement was observed. As there was no proof for TAM had caused the incident, TAM was re-administrated. Eight months after reinstitution of TAM, the same patchy migratory bilateral pulmonary infiltrated with reverse halo sign was found on chest CT with the patient claiming no discomforts nor any clinical symptoms. The diagnosis of TAM-related OP was made based on the exclusion of other causes and recurrence with the re-administration of TAM. The multidisciplinary team (MDT) concluded that TAM should be withdrawn and a “wait-and-see” approach was taken after a comprehensive assessment, instead of altering the medication or performing prophylactic mastectomy. CONCLUSIONS: The withdrawal and rechallenge of TAM strongly suggest that it may play a role as a cofactor in the occurrence of OP after RT for breast cancer, and RT may also be a cofactor in the occurrence of OP. It is extremely important to be alerted to the possibility of OP after concurrent or sequential hormonal therapy and RT. AME Publishing Company 2023-06-13 2023-06-30 /pmc/articles/PMC10316100/ /pubmed/37405001 http://dx.doi.org/10.21037/atm-22-5062 Text en 2023 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Case Report Zhong, Yuting Zhang, Yanjun Liu, Mei Cheng, Liuquan Yang, Junlan Li, Xiru Organising pneumonia caused by hormone (tamoxifen) therapy after radiotherapy for breast cancer: a case report and review of the literature |
title | Organising pneumonia caused by hormone (tamoxifen) therapy after radiotherapy for breast cancer: a case report and review of the literature |
title_full | Organising pneumonia caused by hormone (tamoxifen) therapy after radiotherapy for breast cancer: a case report and review of the literature |
title_fullStr | Organising pneumonia caused by hormone (tamoxifen) therapy after radiotherapy for breast cancer: a case report and review of the literature |
title_full_unstemmed | Organising pneumonia caused by hormone (tamoxifen) therapy after radiotherapy for breast cancer: a case report and review of the literature |
title_short | Organising pneumonia caused by hormone (tamoxifen) therapy after radiotherapy for breast cancer: a case report and review of the literature |
title_sort | organising pneumonia caused by hormone (tamoxifen) therapy after radiotherapy for breast cancer: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316100/ https://www.ncbi.nlm.nih.gov/pubmed/37405001 http://dx.doi.org/10.21037/atm-22-5062 |
work_keys_str_mv | AT zhongyuting organisingpneumoniacausedbyhormonetamoxifentherapyafterradiotherapyforbreastcanceracasereportandreviewoftheliterature AT zhangyanjun organisingpneumoniacausedbyhormonetamoxifentherapyafterradiotherapyforbreastcanceracasereportandreviewoftheliterature AT liumei organisingpneumoniacausedbyhormonetamoxifentherapyafterradiotherapyforbreastcanceracasereportandreviewoftheliterature AT chengliuquan organisingpneumoniacausedbyhormonetamoxifentherapyafterradiotherapyforbreastcanceracasereportandreviewoftheliterature AT yangjunlan organisingpneumoniacausedbyhormonetamoxifentherapyafterradiotherapyforbreastcanceracasereportandreviewoftheliterature AT lixiru organisingpneumoniacausedbyhormonetamoxifentherapyafterradiotherapyforbreastcanceracasereportandreviewoftheliterature |