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Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the most common liver diseases worldwide, affecting approximately 25% of the global population. It is closely associated...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Physiological Society and The Korean Society of Pharmacology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316197/ https://www.ncbi.nlm.nih.gov/pubmed/37386828 http://dx.doi.org/10.4196/kjpp.2023.27.4.299 |
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author | Jin, Yujin Heo, Kyung-Sun |
author_facet | Jin, Yujin Heo, Kyung-Sun |
author_sort | Jin, Yujin |
collection | PubMed |
description | Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the most common liver diseases worldwide, affecting approximately 25% of the global population. It is closely associated with obesity, type 2 diabetes, and metabolic syndrome. Moreover, NAFLD can progress to non-alcoholic steatohepatitis, which can cause liver cirrhosis, liver failure, and hepatocellular carcinoma. Currently, there are no approved drugs for the treatment of NAFLD. Therefore, the development of effective drugs is essential for NAFLD treatment. In this article, we discuss the experimental models and novel therapeutic targets for NAFLD. Additionally, we propose new strategies for the development of drugs for NAFLD. |
format | Online Article Text |
id | pubmed-10316197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Physiological Society and The Korean Society of Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-103161972023-07-04 Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development Jin, Yujin Heo, Kyung-Sun Korean J Physiol Pharmacol Review Article Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the most common liver diseases worldwide, affecting approximately 25% of the global population. It is closely associated with obesity, type 2 diabetes, and metabolic syndrome. Moreover, NAFLD can progress to non-alcoholic steatohepatitis, which can cause liver cirrhosis, liver failure, and hepatocellular carcinoma. Currently, there are no approved drugs for the treatment of NAFLD. Therefore, the development of effective drugs is essential for NAFLD treatment. In this article, we discuss the experimental models and novel therapeutic targets for NAFLD. Additionally, we propose new strategies for the development of drugs for NAFLD. The Korean Physiological Society and The Korean Society of Pharmacology 2023-07-01 2023-07-01 /pmc/articles/PMC10316197/ /pubmed/37386828 http://dx.doi.org/10.4196/kjpp.2023.27.4.299 Text en Copyright © Korean J Physiol Pharmacol https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jin, Yujin Heo, Kyung-Sun Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development |
title | Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development |
title_full | Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development |
title_fullStr | Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development |
title_full_unstemmed | Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development |
title_short | Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development |
title_sort | experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316197/ https://www.ncbi.nlm.nih.gov/pubmed/37386828 http://dx.doi.org/10.4196/kjpp.2023.27.4.299 |
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