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Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development

Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the most common liver diseases worldwide, affecting approximately 25% of the global population. It is closely associated...

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Autores principales: Jin, Yujin, Heo, Kyung-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316197/
https://www.ncbi.nlm.nih.gov/pubmed/37386828
http://dx.doi.org/10.4196/kjpp.2023.27.4.299
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author Jin, Yujin
Heo, Kyung-Sun
author_facet Jin, Yujin
Heo, Kyung-Sun
author_sort Jin, Yujin
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the most common liver diseases worldwide, affecting approximately 25% of the global population. It is closely associated with obesity, type 2 diabetes, and metabolic syndrome. Moreover, NAFLD can progress to non-alcoholic steatohepatitis, which can cause liver cirrhosis, liver failure, and hepatocellular carcinoma. Currently, there are no approved drugs for the treatment of NAFLD. Therefore, the development of effective drugs is essential for NAFLD treatment. In this article, we discuss the experimental models and novel therapeutic targets for NAFLD. Additionally, we propose new strategies for the development of drugs for NAFLD.
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spelling pubmed-103161972023-07-04 Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development Jin, Yujin Heo, Kyung-Sun Korean J Physiol Pharmacol Review Article Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the most common liver diseases worldwide, affecting approximately 25% of the global population. It is closely associated with obesity, type 2 diabetes, and metabolic syndrome. Moreover, NAFLD can progress to non-alcoholic steatohepatitis, which can cause liver cirrhosis, liver failure, and hepatocellular carcinoma. Currently, there are no approved drugs for the treatment of NAFLD. Therefore, the development of effective drugs is essential for NAFLD treatment. In this article, we discuss the experimental models and novel therapeutic targets for NAFLD. Additionally, we propose new strategies for the development of drugs for NAFLD. The Korean Physiological Society and The Korean Society of Pharmacology 2023-07-01 2023-07-01 /pmc/articles/PMC10316197/ /pubmed/37386828 http://dx.doi.org/10.4196/kjpp.2023.27.4.299 Text en Copyright © Korean J Physiol Pharmacol https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jin, Yujin
Heo, Kyung-Sun
Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
title Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
title_full Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
title_fullStr Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
title_full_unstemmed Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
title_short Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
title_sort experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316197/
https://www.ncbi.nlm.nih.gov/pubmed/37386828
http://dx.doi.org/10.4196/kjpp.2023.27.4.299
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