Glucocorticoid receptor-mediated Nr1d1 chromatin circadian misalignment in stress-induced irritable bowel syndrome

Stress-elevated glucocorticoids cause circadian disturbances and gut-brain axis (GBA) disorders, including irritable bowel syndrome (IBS). We hypothesized that the glucocorticoid receptor (GR/NR3C1) might cause chromatin circadian misalignment in the colon epithelium. We observed significantly decre...

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Detalles Bibliográficos
Autores principales: Zheng, Gen, Pang, Suya, Wang, Junbao, Wang, Fangyu, Wang, Qi, Yang, Lili, Ji, Mengdie, Xie, Dejian, Zhu, Shengtao, Chen, Yang, Zhou, Yan, Higgins, Gerald A., Wiley, John W., Hou, Xiaohua, Lin, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316663/
https://www.ncbi.nlm.nih.gov/pubmed/37404374
http://dx.doi.org/10.1016/j.isci.2023.107137

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