Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated l...

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Detalles Bibliográficos
Autores principales: Fidelle, Marine, Tian, Ai-Ling, Zitvogel, Laurence, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316723/
https://www.ncbi.nlm.nih.gov/pubmed/37405191
http://dx.doi.org/10.1080/2162402X.2023.2224672
Descripción
Sumario:In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors.

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