Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated l...

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Detalles Bibliográficos
Autores principales: Fidelle, Marine, Tian, Ai-Ling, Zitvogel, Laurence, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316723/
https://www.ncbi.nlm.nih.gov/pubmed/37405191
http://dx.doi.org/10.1080/2162402X.2023.2224672
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author Fidelle, Marine
Tian, Ai-Ling
Zitvogel, Laurence
Kroemer, Guido
author_facet Fidelle, Marine
Tian, Ai-Ling
Zitvogel, Laurence
Kroemer, Guido
author_sort Fidelle, Marine
collection PubMed
description In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors.
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spelling pubmed-103167232023-07-04 Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance Fidelle, Marine Tian, Ai-Ling Zitvogel, Laurence Kroemer, Guido Oncoimmunology Editorial In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors. Taylor & Francis 2023-06-29 /pmc/articles/PMC10316723/ /pubmed/37405191 http://dx.doi.org/10.1080/2162402X.2023.2224672 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Editorial
Fidelle, Marine
Tian, Ai-Ling
Zitvogel, Laurence
Kroemer, Guido
Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
title Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
title_full Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
title_fullStr Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
title_full_unstemmed Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
title_short Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
title_sort bile acids regulate madcam-1 expression to link the gut microbiota to cancer immunosurveillance
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316723/
https://www.ncbi.nlm.nih.gov/pubmed/37405191
http://dx.doi.org/10.1080/2162402X.2023.2224672
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