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Tocolysis among Women with Preterm Birth: Associated Factors and Outcomes from a Multicenter Study in Brazil

Objective To evaluate the use of tocolysis in cases of preterm birth due to spontaneous preterm labor in a Brazilian sample. Methods A sample of 1,491 women with preterm birth due to spontaneous preterm labor were assessed, considering treatment with tocolysis or expectant management, according to g...

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Autores principales: Dias, Tabata Zumpano, Fava, Mariana Lacerda, Passini Júnior, Renato, Cecatti, Jose Guilherme, Tedesco, Ricardo Porto, Lajos, Giuliane Jesus, Rehder, Patricia Moretti, Nomura, Marcelo Luis, Oliveira, Paulo Fanti, Costa, Maria Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316890/
https://www.ncbi.nlm.nih.gov/pubmed/29747211
http://dx.doi.org/10.1055/s-0038-1642025
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author Dias, Tabata Zumpano
Fava, Mariana Lacerda
Passini Júnior, Renato
Cecatti, Jose Guilherme
Tedesco, Ricardo Porto
Lajos, Giuliane Jesus
Rehder, Patricia Moretti
Nomura, Marcelo Luis
Oliveira, Paulo Fanti
Costa, Maria Laura
author_facet Dias, Tabata Zumpano
Fava, Mariana Lacerda
Passini Júnior, Renato
Cecatti, Jose Guilherme
Tedesco, Ricardo Porto
Lajos, Giuliane Jesus
Rehder, Patricia Moretti
Nomura, Marcelo Luis
Oliveira, Paulo Fanti
Costa, Maria Laura
author_sort Dias, Tabata Zumpano
collection PubMed
description Objective To evaluate the use of tocolysis in cases of preterm birth due to spontaneous preterm labor in a Brazilian sample. Methods A sample of 1,491 women with preterm birth due to spontaneous preterm labor were assessed, considering treatment with tocolysis or expectant management, according to gestational age at birth (< 34 weeks and 34 to 36 + 6 weeks) and drugs prescribed. The study took place in 20 Brazilian hospitals from April 2011 to July 2012. Bivariate analyses were conducted to evaluate associations with sociodemographic and obstetric characteristics and odds ratios with their respective 95% confidence intervals were estimated for maternal and neonatal outcomes. Results A total of 1,491 cases of preterm birth were considered. Tocolysis was performed in 342 cases (23%), 233 of which (68.1%) were delivered before 34 weeks. Within the expectant management group, 73% was late preterm and with more advanced labor at the time of admission. The most used drugs were calcium channel blockers (62.3%), followed by betamimetics (33%). Among the subjects in the tocolysis group, there were more neonatal and maternal complications (majority non-severe) and an occurrence of corticosteroid use that was 29 higher than in the expectant management group. Conclusion Tocolysis is favored in cases of earlier labor and also among those with less than 34 weeks of gestation, using preferably calcium channel blockers, with success in achieving increased corticosteroid use. Tocolysis, in general, was related to higher maternal and neonatal complication rates, which may be due to the baseline difference between cases at admission. However, these results should raise awareness to tocolysis use.
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spelling pubmed-103168902023-07-27 Tocolysis among Women with Preterm Birth: Associated Factors and Outcomes from a Multicenter Study in Brazil Dias, Tabata Zumpano Fava, Mariana Lacerda Passini Júnior, Renato Cecatti, Jose Guilherme Tedesco, Ricardo Porto Lajos, Giuliane Jesus Rehder, Patricia Moretti Nomura, Marcelo Luis Oliveira, Paulo Fanti Costa, Maria Laura Rev Bras Ginecol Obstet Objective To evaluate the use of tocolysis in cases of preterm birth due to spontaneous preterm labor in a Brazilian sample. Methods A sample of 1,491 women with preterm birth due to spontaneous preterm labor were assessed, considering treatment with tocolysis or expectant management, according to gestational age at birth (< 34 weeks and 34 to 36 + 6 weeks) and drugs prescribed. The study took place in 20 Brazilian hospitals from April 2011 to July 2012. Bivariate analyses were conducted to evaluate associations with sociodemographic and obstetric characteristics and odds ratios with their respective 95% confidence intervals were estimated for maternal and neonatal outcomes. Results A total of 1,491 cases of preterm birth were considered. Tocolysis was performed in 342 cases (23%), 233 of which (68.1%) were delivered before 34 weeks. Within the expectant management group, 73% was late preterm and with more advanced labor at the time of admission. The most used drugs were calcium channel blockers (62.3%), followed by betamimetics (33%). Among the subjects in the tocolysis group, there were more neonatal and maternal complications (majority non-severe) and an occurrence of corticosteroid use that was 29 higher than in the expectant management group. Conclusion Tocolysis is favored in cases of earlier labor and also among those with less than 34 weeks of gestation, using preferably calcium channel blockers, with success in achieving increased corticosteroid use. Tocolysis, in general, was related to higher maternal and neonatal complication rates, which may be due to the baseline difference between cases at admission. However, these results should raise awareness to tocolysis use. Thieme Revinter Publicações Ltda 2018-04 /pmc/articles/PMC10316890/ /pubmed/29747211 http://dx.doi.org/10.1055/s-0038-1642025 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Dias, Tabata Zumpano
Fava, Mariana Lacerda
Passini Júnior, Renato
Cecatti, Jose Guilherme
Tedesco, Ricardo Porto
Lajos, Giuliane Jesus
Rehder, Patricia Moretti
Nomura, Marcelo Luis
Oliveira, Paulo Fanti
Costa, Maria Laura
Tocolysis among Women with Preterm Birth: Associated Factors and Outcomes from a Multicenter Study in Brazil
title Tocolysis among Women with Preterm Birth: Associated Factors and Outcomes from a Multicenter Study in Brazil
title_full Tocolysis among Women with Preterm Birth: Associated Factors and Outcomes from a Multicenter Study in Brazil
title_fullStr Tocolysis among Women with Preterm Birth: Associated Factors and Outcomes from a Multicenter Study in Brazil
title_full_unstemmed Tocolysis among Women with Preterm Birth: Associated Factors and Outcomes from a Multicenter Study in Brazil
title_short Tocolysis among Women with Preterm Birth: Associated Factors and Outcomes from a Multicenter Study in Brazil
title_sort tocolysis among women with preterm birth: associated factors and outcomes from a multicenter study in brazil
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316890/
https://www.ncbi.nlm.nih.gov/pubmed/29747211
http://dx.doi.org/10.1055/s-0038-1642025
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