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Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients
Objective To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. Methods Cross-sectional study performed at the Hospital Universitário de...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316933/ https://www.ncbi.nlm.nih.gov/pubmed/29747212 http://dx.doi.org/10.1055/s-0038-1642634 |
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author | Wanderley, Miriam da Silva Pereira, Lara Cristina Ribeiro Santos, Carla Borges Cunha, Vinícius Santos da Neves, Mariam Viviane Jovino |
author_facet | Wanderley, Miriam da Silva Pereira, Lara Cristina Ribeiro Santos, Carla Borges Cunha, Vinícius Santos da Neves, Mariam Viviane Jovino |
author_sort | Wanderley, Miriam da Silva |
collection | PubMed |
description | Objective To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. Methods Cross-sectional study performed at the Hospital Universitário de Brasília (HUB, in the Portuguese acronym) involving PCOS patients diagnosed from January 2011 to January 2013. Four indirect methods, namely, fasting blood insulin level, fasting glucose/insulin ratio (G/I), homeostatic model-assessment-insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI), were used to obtain the IR diagnosis. The data were analyzed using the test of proportions, the Chi-square test, and Fisher exact test, when indicated. Results Out of the 83 patients assessed, aged 28.79 ± 5.85, IR was found in 51.81–66.2% of them using the G/I ratio and the QUICKI, respectively. The test of proportions did not show a significant difference between the methods analyzed. The proportion of IR diagnoses was statistically higher in obese women than in women with normal body mass index (BMI). We observed a statistically significant association between all the methods for diagnosing IR and BMI, waist circumference (WC) and lipid accumulation product (LAP). With regards to arterial hypertension (AH), we observed a significant association according to three methods, with the exception of the ratio G/I. Conclusion Insulin resistance prevalence varied according to the diagnostic method employed, with no statistical difference between them. The proportion of IR diagnoses was statistically higher in obese women than in women with normal BMI. We observed a significant association between IR and WC, BMI, LAP, as well as dyslipidemia and AH in a high proportion of patients. |
format | Online Article Text |
id | pubmed-10316933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Thieme Revinter Publicações Ltda |
record_format | MEDLINE/PubMed |
spelling | pubmed-103169332023-07-27 Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients Wanderley, Miriam da Silva Pereira, Lara Cristina Ribeiro Santos, Carla Borges Cunha, Vinícius Santos da Neves, Mariam Viviane Jovino Rev Bras Ginecol Obstet Objective To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. Methods Cross-sectional study performed at the Hospital Universitário de Brasília (HUB, in the Portuguese acronym) involving PCOS patients diagnosed from January 2011 to January 2013. Four indirect methods, namely, fasting blood insulin level, fasting glucose/insulin ratio (G/I), homeostatic model-assessment-insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI), were used to obtain the IR diagnosis. The data were analyzed using the test of proportions, the Chi-square test, and Fisher exact test, when indicated. Results Out of the 83 patients assessed, aged 28.79 ± 5.85, IR was found in 51.81–66.2% of them using the G/I ratio and the QUICKI, respectively. The test of proportions did not show a significant difference between the methods analyzed. The proportion of IR diagnoses was statistically higher in obese women than in women with normal body mass index (BMI). We observed a statistically significant association between all the methods for diagnosing IR and BMI, waist circumference (WC) and lipid accumulation product (LAP). With regards to arterial hypertension (AH), we observed a significant association according to three methods, with the exception of the ratio G/I. Conclusion Insulin resistance prevalence varied according to the diagnostic method employed, with no statistical difference between them. The proportion of IR diagnoses was statistically higher in obese women than in women with normal BMI. We observed a significant association between IR and WC, BMI, LAP, as well as dyslipidemia and AH in a high proportion of patients. Thieme Revinter Publicações Ltda 2018-04 /pmc/articles/PMC10316933/ /pubmed/29747212 http://dx.doi.org/10.1055/s-0038-1642634 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Wanderley, Miriam da Silva Pereira, Lara Cristina Ribeiro Santos, Carla Borges Cunha, Vinícius Santos da Neves, Mariam Viviane Jovino Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients |
title | Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients |
title_full | Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients |
title_fullStr | Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients |
title_full_unstemmed | Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients |
title_short | Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients |
title_sort | association between insulin resistance and cardiovascular risk factors in polycystic ovary syndrome patients |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316933/ https://www.ncbi.nlm.nih.gov/pubmed/29747212 http://dx.doi.org/10.1055/s-0038-1642634 |
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