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Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients

Objective To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. Methods Cross-sectional study performed at the Hospital Universitário de...

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Autores principales: Wanderley, Miriam da Silva, Pereira, Lara Cristina Ribeiro, Santos, Carla Borges, Cunha, Vinícius Santos da, Neves, Mariam Viviane Jovino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316933/
https://www.ncbi.nlm.nih.gov/pubmed/29747212
http://dx.doi.org/10.1055/s-0038-1642634
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author Wanderley, Miriam da Silva
Pereira, Lara Cristina Ribeiro
Santos, Carla Borges
Cunha, Vinícius Santos da
Neves, Mariam Viviane Jovino
author_facet Wanderley, Miriam da Silva
Pereira, Lara Cristina Ribeiro
Santos, Carla Borges
Cunha, Vinícius Santos da
Neves, Mariam Viviane Jovino
author_sort Wanderley, Miriam da Silva
collection PubMed
description Objective To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. Methods Cross-sectional study performed at the Hospital Universitário de Brasília (HUB, in the Portuguese acronym) involving PCOS patients diagnosed from January 2011 to January 2013. Four indirect methods, namely, fasting blood insulin level, fasting glucose/insulin ratio (G/I), homeostatic model-assessment-insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI), were used to obtain the IR diagnosis. The data were analyzed using the test of proportions, the Chi-square test, and Fisher exact test, when indicated. Results Out of the 83 patients assessed, aged 28.79 ± 5.85, IR was found in 51.81–66.2% of them using the G/I ratio and the QUICKI, respectively. The test of proportions did not show a significant difference between the methods analyzed. The proportion of IR diagnoses was statistically higher in obese women than in women with normal body mass index (BMI). We observed a statistically significant association between all the methods for diagnosing IR and BMI, waist circumference (WC) and lipid accumulation product (LAP). With regards to arterial hypertension (AH), we observed a significant association according to three methods, with the exception of the ratio G/I. Conclusion Insulin resistance prevalence varied according to the diagnostic method employed, with no statistical difference between them. The proportion of IR diagnoses was statistically higher in obese women than in women with normal BMI. We observed a significant association between IR and WC, BMI, LAP, as well as dyslipidemia and AH in a high proportion of patients.
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spelling pubmed-103169332023-07-27 Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients Wanderley, Miriam da Silva Pereira, Lara Cristina Ribeiro Santos, Carla Borges Cunha, Vinícius Santos da Neves, Mariam Viviane Jovino Rev Bras Ginecol Obstet Objective To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. Methods Cross-sectional study performed at the Hospital Universitário de Brasília (HUB, in the Portuguese acronym) involving PCOS patients diagnosed from January 2011 to January 2013. Four indirect methods, namely, fasting blood insulin level, fasting glucose/insulin ratio (G/I), homeostatic model-assessment-insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI), were used to obtain the IR diagnosis. The data were analyzed using the test of proportions, the Chi-square test, and Fisher exact test, when indicated. Results Out of the 83 patients assessed, aged 28.79 ± 5.85, IR was found in 51.81–66.2% of them using the G/I ratio and the QUICKI, respectively. The test of proportions did not show a significant difference between the methods analyzed. The proportion of IR diagnoses was statistically higher in obese women than in women with normal body mass index (BMI). We observed a statistically significant association between all the methods for diagnosing IR and BMI, waist circumference (WC) and lipid accumulation product (LAP). With regards to arterial hypertension (AH), we observed a significant association according to three methods, with the exception of the ratio G/I. Conclusion Insulin resistance prevalence varied according to the diagnostic method employed, with no statistical difference between them. The proportion of IR diagnoses was statistically higher in obese women than in women with normal BMI. We observed a significant association between IR and WC, BMI, LAP, as well as dyslipidemia and AH in a high proportion of patients. Thieme Revinter Publicações Ltda 2018-04 /pmc/articles/PMC10316933/ /pubmed/29747212 http://dx.doi.org/10.1055/s-0038-1642634 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Wanderley, Miriam da Silva
Pereira, Lara Cristina Ribeiro
Santos, Carla Borges
Cunha, Vinícius Santos da
Neves, Mariam Viviane Jovino
Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients
title Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients
title_full Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients
title_fullStr Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients
title_full_unstemmed Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients
title_short Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients
title_sort association between insulin resistance and cardiovascular risk factors in polycystic ovary syndrome patients
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316933/
https://www.ncbi.nlm.nih.gov/pubmed/29747212
http://dx.doi.org/10.1055/s-0038-1642634
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