First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke

Dynamic oxygen-17 ((17)O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this...

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Detalles Bibliográficos
Autores principales: Ebersberger, Louise, Kratzer, Fabian J., Potreck, Arne, Niesporek, Sebastian C., Keymling, Myriam, Nagel, Armin M., Bendszus, Martin, Wick, Wolfgang, Ladd, Mark E., Schlemmer, Heinz-Peter, Hoffmann, Angelika, Platt, Tanja, Paech, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317041/
https://www.ncbi.nlm.nih.gov/pubmed/37404469
http://dx.doi.org/10.3389/fnins.2023.1186558
Descripción
Sumario:Dynamic oxygen-17 ((17)O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this investigation was the first application of dynamic (17)O MRI at 7 Tesla (T) in a patient with stroke. In this proof-of-concept experiment, dynamic (17)O MRI was applied during (17)O inhalation in a patient with early subacute stroke. The analysis of the relative (17)O water (H(2)(17)O) signal for the affected stroke region compared to the healthy contralateral side revealed no significant difference. However, the technical feasibility of (17)O MRI has been demonstrated paving the way for future investigations in neurovascular diseases.

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