First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke

Dynamic oxygen-17 ((17)O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this...

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Autores principales: Ebersberger, Louise, Kratzer, Fabian J., Potreck, Arne, Niesporek, Sebastian C., Keymling, Myriam, Nagel, Armin M., Bendszus, Martin, Wick, Wolfgang, Ladd, Mark E., Schlemmer, Heinz-Peter, Hoffmann, Angelika, Platt, Tanja, Paech, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317041/
https://www.ncbi.nlm.nih.gov/pubmed/37404469
http://dx.doi.org/10.3389/fnins.2023.1186558
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author Ebersberger, Louise
Kratzer, Fabian J.
Potreck, Arne
Niesporek, Sebastian C.
Keymling, Myriam
Nagel, Armin M.
Bendszus, Martin
Wick, Wolfgang
Ladd, Mark E.
Schlemmer, Heinz-Peter
Hoffmann, Angelika
Platt, Tanja
Paech, Daniel
author_facet Ebersberger, Louise
Kratzer, Fabian J.
Potreck, Arne
Niesporek, Sebastian C.
Keymling, Myriam
Nagel, Armin M.
Bendszus, Martin
Wick, Wolfgang
Ladd, Mark E.
Schlemmer, Heinz-Peter
Hoffmann, Angelika
Platt, Tanja
Paech, Daniel
author_sort Ebersberger, Louise
collection PubMed
description Dynamic oxygen-17 ((17)O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this investigation was the first application of dynamic (17)O MRI at 7 Tesla (T) in a patient with stroke. In this proof-of-concept experiment, dynamic (17)O MRI was applied during (17)O inhalation in a patient with early subacute stroke. The analysis of the relative (17)O water (H(2)(17)O) signal for the affected stroke region compared to the healthy contralateral side revealed no significant difference. However, the technical feasibility of (17)O MRI has been demonstrated paving the way for future investigations in neurovascular diseases.
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spelling pubmed-103170412023-07-04 First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke Ebersberger, Louise Kratzer, Fabian J. Potreck, Arne Niesporek, Sebastian C. Keymling, Myriam Nagel, Armin M. Bendszus, Martin Wick, Wolfgang Ladd, Mark E. Schlemmer, Heinz-Peter Hoffmann, Angelika Platt, Tanja Paech, Daniel Front Neurosci Neuroscience Dynamic oxygen-17 ((17)O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this investigation was the first application of dynamic (17)O MRI at 7 Tesla (T) in a patient with stroke. In this proof-of-concept experiment, dynamic (17)O MRI was applied during (17)O inhalation in a patient with early subacute stroke. The analysis of the relative (17)O water (H(2)(17)O) signal for the affected stroke region compared to the healthy contralateral side revealed no significant difference. However, the technical feasibility of (17)O MRI has been demonstrated paving the way for future investigations in neurovascular diseases. Frontiers Media S.A. 2023-06-15 /pmc/articles/PMC10317041/ /pubmed/37404469 http://dx.doi.org/10.3389/fnins.2023.1186558 Text en Copyright © 2023 Ebersberger, Kratzer, Potreck, Niesporek, Keymling, Nagel, Bendszus, Wick, Ladd, Schlemmer, Hoffmann, Platt and Paech. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ebersberger, Louise
Kratzer, Fabian J.
Potreck, Arne
Niesporek, Sebastian C.
Keymling, Myriam
Nagel, Armin M.
Bendszus, Martin
Wick, Wolfgang
Ladd, Mark E.
Schlemmer, Heinz-Peter
Hoffmann, Angelika
Platt, Tanja
Paech, Daniel
First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke
title First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke
title_full First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke
title_fullStr First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke
title_full_unstemmed First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke
title_short First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke
title_sort first application of dynamic oxygen-17 magnetic resonance imaging at 7 tesla in a patient with early subacute stroke
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317041/
https://www.ncbi.nlm.nih.gov/pubmed/37404469
http://dx.doi.org/10.3389/fnins.2023.1186558
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