Targeting the Clear Cell Sarcoma Oncogenic Driver Fusion Gene EWSR1::ATF1 by HDAC Inhibition

Clear cell sarcoma (CCS), a rare but extremely aggressive malignancy with no effective therapy, is characterized by the expression of the oncogenic driver fusion gene EWSR1::ATF1. In this study, we performed a high-throughput drug screening, finding that the histone deacetylase inhibitor vorinostat...

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Detalles Bibliográficos
Autores principales: Mae, Hirokazu, Outani, Hidetatsu, Imura, Yoshinori, Chijimatsu, Ryota, Inoue, Akitomo, Kotani, Yuki, Yasuda, Naohiro, Nakai, Sho, Nakai, Takaaki, Takenaka, Satoshi, Okada, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317042/
https://www.ncbi.nlm.nih.gov/pubmed/37405123
http://dx.doi.org/10.1158/2767-9764.CRC-22-0518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317042/
https://www.ncbi.nlm.nih.gov/pubmed/37405123
http://dx.doi.org/10.1158/2767-9764.CRC-22-0518

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