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Capturing the domain crosstalk in full length LRRK2 and LRRK2(RCKW)

LRR-kinase 2 (LRRK2) is a multi-domain protein with three catalytically inert N-terminal domains (NtDs) and four C-terminal domains, including a kinase and a GTPase domain. LRRK2 mutations are linked to Parkinson's Disease (PD). Recent structures of LRRK2(RCKW) and a full-length inactive LRRK2...

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Detalles Bibliográficos
Autores principales:	Störmer, Eliza, Weng, Jui-Hung, Wu, Jian, Bertinetti, Daniela, Kaila Sharma, Pallavi, Ma, Wen, Herberg, Friedrich W., Taylor, Susan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2023
Materias:	Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317166/ https://www.ncbi.nlm.nih.gov/pubmed/37212165 http://dx.doi.org/10.1042/BCJ20230126

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