Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase

Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine (C) or adenine (A), but no method for guanine (G) or thymine (T) editing is available at present. Here we developed a deaminase-free glycosylase-based guanine base editor (gGBE) with G editing ability, b...

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Detalles Bibliográficos
Autores principales: Tong, Huawei, Liu, Nana, Wei, Yinghui, Zhou, Yingsi, Li, Yun, Wu, Danni, Jin, Ming, Cui, Shuna, Li, Hengbin, Li, Guoling, Zhou, Jingxing, Yuan, Yuan, Zhang, Hainan, Shi, Linyu, Yao, Xuan, Yang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317176/
https://www.ncbi.nlm.nih.gov/pubmed/37404457
http://dx.doi.org/10.1093/nsr/nwad143

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