Radioembolization Planning With Dual-Isotope Acquisition of (166)Ho-Labeled Microparticles and (99m)Tc-Mebrofenin

A 76-year-old man with hepatocellular carcinoma was referred for liver radioembolization. Given a prior left hemihepatectomy, it was clinically important to consider potentially irradiated healthy liver at planning. Thus, at the SPECT/CT imaging of the scout dose (166)Ho-microparticles before inject...

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Autores principales: Czibor, Sándor, Bibok, András, Horváthy, Dénes, Fábián, Krisztián, Györke, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317298/
https://www.ncbi.nlm.nih.gov/pubmed/37290424
http://dx.doi.org/10.1097/RLU.0000000000004732
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author Czibor, Sándor
Bibok, András
Horváthy, Dénes
Fábián, Krisztián
Györke, Tamás
author_facet Czibor, Sándor
Bibok, András
Horváthy, Dénes
Fábián, Krisztián
Györke, Tamás
author_sort Czibor, Sándor
collection PubMed
description A 76-year-old man with hepatocellular carcinoma was referred for liver radioembolization. Given a prior left hemihepatectomy, it was clinically important to consider potentially irradiated healthy liver at planning. Thus, at the SPECT/CT imaging of the scout dose (166)Ho-microparticles before injected superselectively in the right hepatic artery, (99m)Tc-mebrofenin was injected intravenously, and functional volumetry SPECT was performed simultaneously. Based on the 2 image sets, the nonirradiated healthy liver was calculated as 1589 mL (functional liver reserve of 85.5% on (99m)Tc-mebrofenin SPECT). Posttreatment dosimetry calculations showed optimal normal tissue and tumor absorbed doses, and the patient is clinically well after 3 months.
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spelling pubmed-103172982023-07-04 Radioembolization Planning With Dual-Isotope Acquisition of (166)Ho-Labeled Microparticles and (99m)Tc-Mebrofenin Czibor, Sándor Bibok, András Horváthy, Dénes Fábián, Krisztián Györke, Tamás Clin Nucl Med Interesting Images A 76-year-old man with hepatocellular carcinoma was referred for liver radioembolization. Given a prior left hemihepatectomy, it was clinically important to consider potentially irradiated healthy liver at planning. Thus, at the SPECT/CT imaging of the scout dose (166)Ho-microparticles before injected superselectively in the right hepatic artery, (99m)Tc-mebrofenin was injected intravenously, and functional volumetry SPECT was performed simultaneously. Based on the 2 image sets, the nonirradiated healthy liver was calculated as 1589 mL (functional liver reserve of 85.5% on (99m)Tc-mebrofenin SPECT). Posttreatment dosimetry calculations showed optimal normal tissue and tumor absorbed doses, and the patient is clinically well after 3 months. Lippincott Williams & Wilkins 2023-08 2023-06-08 /pmc/articles/PMC10317298/ /pubmed/37290424 http://dx.doi.org/10.1097/RLU.0000000000004732 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Interesting Images
Czibor, Sándor
Bibok, András
Horváthy, Dénes
Fábián, Krisztián
Györke, Tamás
Radioembolization Planning With Dual-Isotope Acquisition of (166)Ho-Labeled Microparticles and (99m)Tc-Mebrofenin
title Radioembolization Planning With Dual-Isotope Acquisition of (166)Ho-Labeled Microparticles and (99m)Tc-Mebrofenin
title_full Radioembolization Planning With Dual-Isotope Acquisition of (166)Ho-Labeled Microparticles and (99m)Tc-Mebrofenin
title_fullStr Radioembolization Planning With Dual-Isotope Acquisition of (166)Ho-Labeled Microparticles and (99m)Tc-Mebrofenin
title_full_unstemmed Radioembolization Planning With Dual-Isotope Acquisition of (166)Ho-Labeled Microparticles and (99m)Tc-Mebrofenin
title_short Radioembolization Planning With Dual-Isotope Acquisition of (166)Ho-Labeled Microparticles and (99m)Tc-Mebrofenin
title_sort radioembolization planning with dual-isotope acquisition of (166)ho-labeled microparticles and (99m)tc-mebrofenin
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317298/
https://www.ncbi.nlm.nih.gov/pubmed/37290424
http://dx.doi.org/10.1097/RLU.0000000000004732
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