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Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms

Opioids depress breathing by inhibition of interconnected respiratory nuclei in the pons and medulla. Mu opioid receptor (MOR) agonists directly hyperpolarize a population of neurons in the dorsolateral pons, particularly the Kölliker-Fuse (KF) nucleus, that are key mediators of opioid-induced respi...

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Detalles Bibliográficos
Autores principales: Bateman, Jordan T, Levitt, Erica S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317500/
https://www.ncbi.nlm.nih.gov/pubmed/37314062
http://dx.doi.org/10.7554/eLife.81119