Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model

The persistence of leukemic stem cells (LSCs) represents a problem in the therapy of chronic myeloid leukemia (CML). Hence, it is of utmost importance to explore the underlying mechanisms to develop new therapeutic approaches to cure CML. Using the genetically engineered ScltTA/TRE-BCR::ABL1 mouse m...

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Detalles Bibliográficos
Autores principales: Langhammer, Melanie, Schöpf, Julia, Jaquet, Timo, Horn, Katharina, Angel, Moritz, Spohr, Corinna, Christen, Daniel, Uhl, Franziska Maria, Maié, Tiago, Jacobi, Henrike, Feyerabend, Thorsten B., Huber, Julia, Panning, Marcus, Sitaru, Cassian, Costa, Ivan, Zeiser, Robert, Aumann, Konrad, Becker, Heiko, Braunschweig, Till, Koschmieder, Steffen, Shoumariyeh, Khalid, Huber, Michael, Schemionek-Reinders, Mirle, Brummer, Tilman, Halbach, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317838/
https://www.ncbi.nlm.nih.gov/pubmed/37161070
http://dx.doi.org/10.1038/s41375-023-01916-x

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