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Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group
PURPOSE: Radical resection (R0) represents the best curative treatment for local recurrence (LR) rectal cancer. Re-irradiation (re-RT) can increase the rate of R0 resection. Currently, there is a lack of guidelines on Re-RT for LR rectal cancer. The Italian Association of Radiation and clinical onco...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317862/ https://www.ncbi.nlm.nih.gov/pubmed/37365381 http://dx.doi.org/10.1007/s11547-023-01652-3 |
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author | Mantello, Giovanna Galofaro, Elena Caravatta, Luciana Di Carlo, Clelia Montrone, Sabrina Arpa, Donatella Chiloiro, Giuditta De Paoli, Antonino Donato, Vittorio Gambacorta, Maria Antonietta Genovesi, Domenico Lupattelli, Marco Macchia, Gabriella Montesi, Giampaolo Niespolo, Rita Marina Palazzari, Elisa Pontoriero, Antonio Scricciolo, Melissa Valvo, Francesca Franco, Pierfrancesco |
author_facet | Mantello, Giovanna Galofaro, Elena Caravatta, Luciana Di Carlo, Clelia Montrone, Sabrina Arpa, Donatella Chiloiro, Giuditta De Paoli, Antonino Donato, Vittorio Gambacorta, Maria Antonietta Genovesi, Domenico Lupattelli, Marco Macchia, Gabriella Montesi, Giampaolo Niespolo, Rita Marina Palazzari, Elisa Pontoriero, Antonio Scricciolo, Melissa Valvo, Francesca Franco, Pierfrancesco |
author_sort | Mantello, Giovanna |
collection | PubMed |
description | PURPOSE: Radical resection (R0) represents the best curative treatment for local recurrence (LR) rectal cancer. Re-irradiation (re-RT) can increase the rate of R0 resection. Currently, there is a lack of guidelines on Re-RT for LR rectal cancer. The Italian Association of Radiation and clinical oncology for gastrointestinal tumors (AIRO-GI) study group released a national survey to investigate the current clinical practice of external beam radiation therapy in these patients. MATERIAL AND METHODS: In February 2021, the survey was designed and distributed to members of the GI working group. The questionnaire consisted of 40 questions regarding center characteristics, clinical indications, doses, and treatment techniques of re-RT for LR rectal cancer. RESULTS: A total of 37 questionnaires were collected. Re-RT was reported as an option for neoadjuvant treatment in resectable and unresectable disease by 55% and 75% of respondents, respectively. Long-course treatment with 30–40 Gy (1.8–2 Gy/die, 1.2 Gy bid) and hypofractionated regimen of 30–35 Gy in 5 fractions were used in most centers. A total dose of 90–100 Gy as EqD2 dose (α/β = 5 Gy) was delivered by 46% of the respondents considering the previous treatment. Modern conformal techniques and daily image-guided radiation therapy protocols were used in 94% of centers. CONCLUSION: Our survey showed that re-RT treatment is performed with advanced technology that allow a good management of LR rectal cancer. Significant variations were observed in terms of dose and fractionation, highlighting the need for a consensus on a common treatment strategy that could be validated in prospective studies. |
format | Online Article Text |
id | pubmed-10317862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-103178622023-07-05 Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group Mantello, Giovanna Galofaro, Elena Caravatta, Luciana Di Carlo, Clelia Montrone, Sabrina Arpa, Donatella Chiloiro, Giuditta De Paoli, Antonino Donato, Vittorio Gambacorta, Maria Antonietta Genovesi, Domenico Lupattelli, Marco Macchia, Gabriella Montesi, Giampaolo Niespolo, Rita Marina Palazzari, Elisa Pontoriero, Antonio Scricciolo, Melissa Valvo, Francesca Franco, Pierfrancesco Radiol Med Radiotherapy PURPOSE: Radical resection (R0) represents the best curative treatment for local recurrence (LR) rectal cancer. Re-irradiation (re-RT) can increase the rate of R0 resection. Currently, there is a lack of guidelines on Re-RT for LR rectal cancer. The Italian Association of Radiation and clinical oncology for gastrointestinal tumors (AIRO-GI) study group released a national survey to investigate the current clinical practice of external beam radiation therapy in these patients. MATERIAL AND METHODS: In February 2021, the survey was designed and distributed to members of the GI working group. The questionnaire consisted of 40 questions regarding center characteristics, clinical indications, doses, and treatment techniques of re-RT for LR rectal cancer. RESULTS: A total of 37 questionnaires were collected. Re-RT was reported as an option for neoadjuvant treatment in resectable and unresectable disease by 55% and 75% of respondents, respectively. Long-course treatment with 30–40 Gy (1.8–2 Gy/die, 1.2 Gy bid) and hypofractionated regimen of 30–35 Gy in 5 fractions were used in most centers. A total dose of 90–100 Gy as EqD2 dose (α/β = 5 Gy) was delivered by 46% of the respondents considering the previous treatment. Modern conformal techniques and daily image-guided radiation therapy protocols were used in 94% of centers. CONCLUSION: Our survey showed that re-RT treatment is performed with advanced technology that allow a good management of LR rectal cancer. Significant variations were observed in terms of dose and fractionation, highlighting the need for a consensus on a common treatment strategy that could be validated in prospective studies. Springer Milan 2023-06-26 2023 /pmc/articles/PMC10317862/ /pubmed/37365381 http://dx.doi.org/10.1007/s11547-023-01652-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Radiotherapy Mantello, Giovanna Galofaro, Elena Caravatta, Luciana Di Carlo, Clelia Montrone, Sabrina Arpa, Donatella Chiloiro, Giuditta De Paoli, Antonino Donato, Vittorio Gambacorta, Maria Antonietta Genovesi, Domenico Lupattelli, Marco Macchia, Gabriella Montesi, Giampaolo Niespolo, Rita Marina Palazzari, Elisa Pontoriero, Antonio Scricciolo, Melissa Valvo, Francesca Franco, Pierfrancesco Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group |
title | Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group |
title_full | Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group |
title_fullStr | Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group |
title_full_unstemmed | Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group |
title_short | Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group |
title_sort | pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the airo gastrointestinal tumors study group |
topic | Radiotherapy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317862/ https://www.ncbi.nlm.nih.gov/pubmed/37365381 http://dx.doi.org/10.1007/s11547-023-01652-3 |
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