Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood

AIMS/HYPOTHESIS: Determining how high BMI at different time points influences the risk of developing type 2 diabetes and affects insulin secretion and insulin sensitivity is critical. METHODS: By estimating childhood BMI in 441,761 individuals in the UK Biobank, we identified which genetic variants...

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Detalles Bibliográficos
Autores principales: Hawkes, Gareth, Beaumont, Robin N., Tyrrell, Jessica, Power, Grace M., Wood, Andrew, Laakso, Markku, Fernandes Silva, Lilian, Boehnke, Michael, Yin, Xianyong, Richardson, Tom G., Smith, George Davey, Frayling, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317883/
https://www.ncbi.nlm.nih.gov/pubmed/37280435
http://dx.doi.org/10.1007/s00125-023-05923-6

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