Fibroblast activation protein targeted radiotherapy induces an immunogenic tumor microenvironment and enhances the efficacy of PD-1 immune checkpoint inhibition

PURPOSE: FAP is a membrane-bound protease under investigation as a pan-cancer target, given its high levels in tumors but limited expression in normal tissues. FAP-2286 is a radiopharmaceutical in clinical development for solid tumors that consists of two functional elements: a FAP-targeting peptide...

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Detalles Bibliográficos
Autores principales: Zboralski, Dirk, Osterkamp, Frank, Christensen, Esben, Bredenbeck, Anne, Schumann, Anne, Hoehne, Aileen, Schneider, Eberhard, Paschke, Matthias, Ungewiss, Jan, Haase, Christian, Robillard, Liliane, Simmons, Andrew D., Harding, Thomas C., Nguyen, Minh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317891/
https://www.ncbi.nlm.nih.gov/pubmed/37086273
http://dx.doi.org/10.1007/s00259-023-06211-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317891/
https://www.ncbi.nlm.nih.gov/pubmed/37086273
http://dx.doi.org/10.1007/s00259-023-06211-6

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