Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens

YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo pathway, while, in Uveal Melanoma (UM), YAP is activated in...

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Detalles Bibliográficos
Autores principales: Barbosa, Inês A. M., Gopalakrishnan, Rajaraman, Mercan, Samuele, Mourikis, Thanos P., Martin, Typhaine, Wengert, Simon, Sheng, Caibin, Ji, Fei, Lopes, Rui, Knehr, Judith, Altorfer, Marc, Lindeman, Alicia, Russ, Carsten, Naumann, Ulrike, Golji, Javad, Sprouffske, Kathleen, Barys, Louise, Tordella, Luca, Schübeler, Dirk, Schmelzle, Tobias, Galli, Giorgio G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317959/
https://www.ncbi.nlm.nih.gov/pubmed/37400441
http://dx.doi.org/10.1038/s41467-023-39527-w

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