Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA(A) receptor transport in a murine model

The pathophysiological mechanisms underlying epileptogenesis are poorly understood but are considered to actively involve an imbalance between excitatory and inhibitory synaptic transmission. Excessive activation of autophagy, a cellular pathway that leads to the removal of proteins, is known to agg...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Ke, Pingyang, Guo, Haokun, Gu, Juan, Liu, Yan, Tian, Xin, Wang, Xuefeng, Xiao, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317981/
https://www.ncbi.nlm.nih.gov/pubmed/37258573
http://dx.doi.org/10.1038/s12276-023-01000-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317981/
https://www.ncbi.nlm.nih.gov/pubmed/37258573
http://dx.doi.org/10.1038/s12276-023-01000-5

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