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The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling

The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that exposure to the representative tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) promotes lung tumorigenesis thro...

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Detalles Bibliográficos
Autores principales:	Boo, Hye-Jin, Min, Hye-Young, Hwang, Su Jung, Lee, Hyo-Jong, Lee, Jae-Won, Oh, Sei-Ryang, Park, Choon-Sik, Park, Jong-Sook, Lee, You Mie, Lee, Ho-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317988/ https://www.ncbi.nlm.nih.gov/pubmed/37258578 http://dx.doi.org/10.1038/s12276-023-00994-2

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