Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumula...

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Autores principales: Han, Kyung Ah, Ko, Jaewon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318009/
https://www.ncbi.nlm.nih.gov/pubmed/37258575
http://dx.doi.org/10.1038/s12276-023-01004-1
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author Han, Kyung Ah
Ko, Jaewon
author_facet Han, Kyung Ah
Ko, Jaewon
author_sort Han, Kyung Ah
collection PubMed
description The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.
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spelling pubmed-103180092023-07-05 Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization Han, Kyung Ah Ko, Jaewon Exp Mol Med Review Article The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders. Nature Publishing Group UK 2023-06-01 /pmc/articles/PMC10318009/ /pubmed/37258575 http://dx.doi.org/10.1038/s12276-023-01004-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Han, Kyung Ah
Ko, Jaewon
Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
title Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
title_full Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
title_fullStr Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
title_full_unstemmed Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
title_short Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
title_sort orchestration of synaptic functions by wave regulatory complex-mediated actin reorganization
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318009/
https://www.ncbi.nlm.nih.gov/pubmed/37258575
http://dx.doi.org/10.1038/s12276-023-01004-1
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AT kojaewon orchestrationofsynapticfunctionsbywaveregulatorycomplexmediatedactinreorganization

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