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SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence

SIRT1, a member of the mammalian sirtuin family, is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase with key roles in aging-related diseases and cellular senescence. However, the mechanism by which SIRT1 protein homeostasis is controlled under senescent conditions remains elusive....

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Detalles Bibliográficos
Autores principales:	Lee, Sang Hyup, Yang, Ji-Hye, Park, Ui-Hyun, Choi, Hanbyeul, Kim, Yoo Sung, Yoon, Bo-Eun, Han, Hye-Jeong, Kim, Hyun-Taek, Um, Soo-Jong, Kim, Eun-Joo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318011/ https://www.ncbi.nlm.nih.gov/pubmed/37258580 http://dx.doi.org/10.1038/s12276-023-01012-1

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