Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages

Hepatic insulin resistance is recognized as a driver of type 2 diabetes and fatty liver disease but specific therapies are lacking. Here we explore the potential of human induced pluripotent stem cells (iPSCs) for modeling hepatic insulin resistance in vitro, with a focus on resolving the controvers...

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Detalles Bibliográficos
Autores principales: Groeger, Marko, Matsuo, Koji, Heidary Arash, Emad, Pereira, Ashley, Le Guillou, Dounia, Pino, Cindy, Telles-Silva, Kayque A., Maher, Jacquelyn J., Hsiao, Edward C., Willenbring, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318012/
https://www.ncbi.nlm.nih.gov/pubmed/37400454
http://dx.doi.org/10.1038/s41467-023-39311-w

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