Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs. p27 phosphorylation by CDK1/2, signals its recruitment to the SCF(SKP2) (S-phase kinase associated protein 1 (SKP1)-cullin-SKP2) E3 ubiquiti...

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Detalles Bibliográficos
Autores principales: Rowland, Rhianna J., Heath, Richard, Maskell, Daniel, Thompson, Rebecca F., Ranson, Neil A., Blaza, James N., Endicott, Jane A., Noble, Martin E. M., Salamina, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318019/
https://www.ncbi.nlm.nih.gov/pubmed/37400515
http://dx.doi.org/10.1038/s41598-023-37609-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318019/
https://www.ncbi.nlm.nih.gov/pubmed/37400515
http://dx.doi.org/10.1038/s41598-023-37609-9

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