Determining buffer conditions for downstream processing of VLP-based recombinant hepatitis B surface antigen using multimodal resins in bind-elute and flow-through purification modes

The difficulties in purification of VLP-based recombinant hepatitis B surface antigen (rHBsAg) are mainly emerged from inefficient semi-purification step plus proteins physicochemical properties and these issues make the downstream processing (DSP) very lengthy and expensive. In this study, optimiza...

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Detalles Bibliográficos
Autores principales: Goodarzi, Maryam Moazami, Jalalirad, Reza, Doroud, Delaram, Hozouri, Hamidreza, Aghasadeghi, Mohammadreza, Paryan, Mahdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318023/
https://www.ncbi.nlm.nih.gov/pubmed/37400485
http://dx.doi.org/10.1038/s41598-023-37614-y

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