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Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated 2-alkylquinolones with proinflammatory host response

The human pathogen Pseudomonas aeruginosa produces various 4(1H)-quinolones with diverse functions. Among these, 2-nonyl-4(1H)-quinolone (NQ) and its N-oxide (NQNO) belong to the main metabolites. Their biosynthesis involves substrates from the fatty acid metabolism and we hypothesized that oxidized...

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Detalles Bibliográficos
Autores principales:	Savchenko, Viktoriia, Szamosvári, Dávid, Bao, Yifan, Pignitter, Marc, Böttcher, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318067/ https://www.ncbi.nlm.nih.gov/pubmed/37400564 http://dx.doi.org/10.1038/s42004-023-00937-y

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